Lloyd MD - Search Results

1

Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors.

Cozier GE, Leese MP, Lloyd MD, Baker MD, Thiyagarajan N, Acharya KR, Potter BV. Cozier GE, et al. Among authors: lloyd md. Biochemistry. 2010 Apr 27;49(16):3464-76. doi: 10.1021/bi902178w. Biochemistry. 2010. PMID: 20297840

2

Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent.

Lloyd MD, Pederick RL, Natesh R, Woo LW, Purohit A, Reed MJ, Acharya KR, Potter BV. Lloyd MD, et al. Biochem J. 2005 Feb 1;385(Pt 3):715-20. doi: 10.1042/BJ20041037. Biochem J. 2005. PMID: 15453828 Free PMC article.

3

The advantages and limitations of protein crystal structures.

Acharya KR, Lloyd MD. Acharya KR, et al. Among authors: lloyd md. Trends Pharmacol Sci. 2005 Jan;26(1):10-4. doi: 10.1016/j.tips.2004.10.011. Trends Pharmacol Sci. 2005. PMID: 15629199 Review.

4

First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.

Lloyd MD, Thiyagarajan N, Ho YT, Woo LW, Sutcliffe OB, Purohit A, Reed MJ, Acharya KR, Potter BV. Lloyd MD, et al. Biochemistry. 2005 May 10;44(18):6858-66. doi: 10.1021/bi047692e. Biochemistry. 2005. PMID: 15865431

5

Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1.

Holbourn KP, Lloyd MD, Thompson AS, Threadgill MD, Acharya KR. Holbourn KP, et al. Among authors: lloyd md. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):461-3. doi: 10.1107/S1744309111003277. Epub 2011 Mar 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21505241 Free PMC article.

6

α-Methylacyl-CoA Racemase from Mycobacterium tuberculosis-Detailed Kinetic and Structural Characterization of the Active Site.

Mojanaga OO, Woodman TJ, Lloyd MD, Acharya KR. Mojanaga OO, et al. Among authors: lloyd md. Biomolecules. 2024 Mar 2;14(3):299. doi: 10.3390/biom14030299. Biomolecules. 2024. PMID: 38540719 Free PMC article.

7

Functional implications of unusual NOS and SONOS covalent linkages found in proteins.

Lloyd MD, Gregory KS, Acharya KR. Lloyd MD, et al. Chem Commun (Camb). 2024 Aug 29;60(71):9463-9471. doi: 10.1039/d4cc03191a. Chem Commun (Camb). 2024. PMID: 39109843 Review.

8

Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.

Lord AM, Mahon MF, Lloyd MD, Threadgill MD. Lord AM, et al. Among authors: lloyd md. J Med Chem. 2009 Feb 12;52(3):868-77. doi: 10.1021/jm8013629. J Med Chem. 2009. PMID: 19117416

9

5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).

Sunderland PT, Woon EC, Dhami A, Bergin AB, Mahon MF, Wood PJ, Jones LA, Tully SR, Lloyd MD, Thompson AS, Javaid H, Martin NM, Threadgill MD. Sunderland PT, et al. Among authors: lloyd md. J Med Chem. 2011 Apr 14;54(7):2049-59. doi: 10.1021/jm1010918. Epub 2011 Mar 18. J Med Chem. 2011. PMID: 21417348 Free article.

10

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.

Paine HA, Nathubhai A, Woon EC, Sunderland PT, Wood PJ, Mahon MF, Lloyd MD, Thompson AS, Haikarainen T, Narwal M, Lehtiö L, Threadgill MD. Paine HA, et al. Among authors: lloyd md. Bioorg Med Chem. 2015 Sep 1;23(17):5891-908. doi: 10.1016/j.bmc.2015.06.061. Epub 2015 Jul 2. Bioorg Med Chem. 2015. PMID: 26189030

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