De Clercq E - Search Results

1

Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.

Skerlj RT, Bridger GJ, Kaller A, McEachern EJ, Crawford JB, Zhou Y, Atsma B, Langille J, Nan S, Veale D, Wilson T, Harwig C, Hatse S, Princen K, De Clercq E, Schols D. Skerlj RT, et al. Among authors: de clercq e. J Med Chem. 2010 Apr 22;53(8):3376-88. doi: 10.1021/jm100073m. J Med Chem. 2010. PMID: 20297846

2

A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.

Naif HM, Cunningham AL, Alali M, Li S, Nasr N, Buhler MM, Schols D, de Clercq E, Stewart G. Naif HM, et al. Among authors: de clercq e. J Virol. 2002 Apr;76(7):3114-24. doi: 10.1128/jvi.76.7.3114-3124.2002. J Virol. 2002. PMID: 11884536 Free PMC article.

3

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

Hatse S, Princen K, Bridger G, De Clercq E, Schols D. Hatse S, et al. Among authors: de clercq e. FEBS Lett. 2002 Sep 11;527(1-3):255-62. doi: 10.1016/s0014-5793(02)03143-5. FEBS Lett. 2002. PMID: 12220670 Free article.

4

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.

Barreca ML, Balzarini J, Chimirri A, De Clercq E, De Luca L, Höltje HD, Höltje M, Monforte AM, Monforte P, Pannecouque C, Rao A, Zappalà M. Barreca ML, et al. Among authors: de luca l, de clercq e. J Med Chem. 2002 Nov 21;45(24):5410-3. doi: 10.1021/jm020977+. J Med Chem. 2002. PMID: 12431069

5

CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor.

Vermeire K, Zhang Y, Princen K, Hatse S, Samala MF, Dey K, Choi HJ, Ahn Y, Sodoma A, Snoeck R, Andrei G, De Clercq E, Bell TW, Schols D. Vermeire K, et al. Among authors: de clercq e. Virology. 2002 Oct 25;302(2):342-53. doi: 10.1006/viro.2002.1624. Virology. 2002. PMID: 12441078 Free article.

6

Polysulfonates derived from metal thiolate complexes as inhibitors of HIV-1 and various other enveloped viruses in vitro.

Bergstrom DE, Lin X, Wood TD, Witvrouw M, Ikeda S, Andrei G, Snoeck R, Schols D, De Clercq E. Bergstrom DE, et al. Among authors: de clercq e. Antivir Chem Chemother. 2002 May;13(3):185-95. doi: 10.1177/095632020201300305. Antivir Chem Chemother. 2002. PMID: 12448691 Free article.

7

The Anti-HIV potency of cyclotriazadisulfonamide analogs is directly correlated with their ability to down-modulate the CD4 receptor.

Vermeire K, Bell TW, Choi HJ, Jin Q, Samala MF, Sodoma A, De Clercq E, Schols D. Vermeire K, et al. Among authors: de clercq e. Mol Pharmacol. 2003 Jan;63(1):203-10. doi: 10.1124/mol.63.1.203. Mol Pharmacol. 2003. PMID: 12488553

8

Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry.

Princen K, Hatse S, Vermeire K, De Clercq E, Schols D. Princen K, et al. Among authors: de clercq e. Cytometry A. 2003 Jan;51(1):35-45. doi: 10.1002/cyto.a.10008. Cytometry A. 2003. PMID: 12500303 Free article.

9

Reduced fitness of HIV-1 resistant to CXCR4 antagonists.

Armand-Ugón M, Quiñones-Mateu ME, Gutiérez A, Barretina J, Blanco J, Schols D, De Clercq E, Clotet B, Esté JA. Armand-Ugón M, et al. Among authors: de clercq e. Antivir Ther. 2003 Feb;8(1):1-8. Antivir Ther. 2003. PMID: 12713058

10

Identification of a subset of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains able to exploit an alternative coreceptor on untransformed human brain and lymphoid cells.

Willey SJ, Reeves JD, Hudson R, Miyake K, Dejucq N, Schols D, De Clercq E, Bell J, McKnight A, Clapham PR. Willey SJ, et al. Among authors: de clercq e. J Virol. 2003 Jun;77(11):6138-52. doi: 10.1128/jvi.77.11.6138-6152.2003. J Virol. 2003. PMID: 12743271 Free PMC article.

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