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A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D. Lai MT, et al. Among authors: li ym. J Neurochem. 2006 Jan;96(1):118-25. doi: 10.1111/j.1471-4159.2005.03528.x. Epub 2005 Nov 21. J Neurochem. 2006. PMID: 16300640 Free article.
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Kounnas MZ, et al. Among authors: li ym. Neuron. 2010 Sep 9;67(5):769-80. doi: 10.1016/j.neuron.2010.08.018. Neuron. 2010. PMID: 20826309 Free PMC article.
Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.
Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, Thinakaran G. Vetrivel KS, et al. Among authors: li ym. J Biol Chem. 2008 Jul 11;283(28):19489-98. doi: 10.1074/jbc.M801037200. Epub 2008 May 1. J Biol Chem. 2008. PMID: 18456655 Free PMC article.
2,690 results