Okuhira K - Search Results

1

Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.

Okuhira K, Fitzgerald ML, Tamehiro N, Ohoka N, Suzuki K, Sawada J, Naito M, Nishimaki-Mogami T. Okuhira K, et al. J Biol Chem. 2010 May 21;285(21):16369-77. doi: 10.1074/jbc.M109.061424. Epub 2010 Mar 26. J Biol Chem. 2010. PMID: 20348106 Free PMC article.

2

Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis.

Tanaka AR, Abe-Dohmae S, Ohnishi T, Aoki R, Morinaga G, Okuhira K, Ikeda Y, Kano F, Matsuo M, Kioka N, Amachi T, Murata M, Yokoyama S, Ueda K. Tanaka AR, et al. Among authors: okuhira k. J Biol Chem. 2003 Mar 7;278(10):8815-9. doi: 10.1074/jbc.M206885200. Epub 2002 Dec 31. J Biol Chem. 2003. PMID: 12509412 Free article.

3

Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.

Abe-Dohmae S, Ikeda Y, Matsuo M, Hayashi M, Okuhira K, Ueda K, Yokoyama S. Abe-Dohmae S, et al. Among authors: okuhira k. J Biol Chem. 2004 Jan 2;279(1):604-11. doi: 10.1074/jbc.M309888200. Epub 2003 Oct 21. J Biol Chem. 2004. PMID: 14570867 Free article.

4

ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities.

Fitzgerald ML, Okuhira K, Short GF 3rd, Manning JJ, Bell SA, Freeman MW. Fitzgerald ML, et al. Among authors: okuhira k. J Biol Chem. 2004 Nov 12;279(46):48477-85. doi: 10.1074/jbc.M409848200. Epub 2004 Sep 3. J Biol Chem. 2004. PMID: 15347662 Free article.

5

Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.

Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, Manning JJ, Koehn SL, Lu N, Moore KJ, Freeman MW. Kim WS, et al. Among authors: okuhira k. J Biol Chem. 2005 Feb 4;280(5):3989-95. doi: 10.1074/jbc.M412602200. Epub 2004 Nov 17. J Biol Chem. 2005. PMID: 15550377 Free article.

6

Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.

Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW. Okuhira K, et al. J Biol Chem. 2005 Nov 25;280(47):39653-64. doi: 10.1074/jbc.M510187200. Epub 2005 Sep 28. J Biol Chem. 2005. PMID: 16192269 Free article.

7

Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status.

Tamehiro N, Shigemoto-Mogami Y, Kakeya T, Okuhira K, Suzuki K, Sato R, Nagao T, Nishimaki-Mogami T. Tamehiro N, et al. Among authors: okuhira k. J Biol Chem. 2007 Jul 20;282(29):21090-9. doi: 10.1074/jbc.M701228200. Epub 2007 May 27. J Biol Chem. 2007. PMID: 17526932 Free article.

8

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.

Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML. Tamehiro N, et al. Among authors: okuhira k. Biochemistry. 2008 Jun 10;47(23):6138-47. doi: 10.1021/bi800182t. Epub 2008 May 17. Biochemistry. 2008. PMID: 18484747 Free PMC article.

9

The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines.

Nishimaki-Mogami T, Tamehiro N, Sato Y, Okuhira K, Sai K, Kagechika H, Shudo K, Abe-Dohmae S, Yokoyama S, Ohno Y, Inoue K, Sawada J. Nishimaki-Mogami T, et al. Among authors: okuhira k. Biochem Pharmacol. 2008 Oct 15;76(8):1006-13. doi: 10.1016/j.bcp.2008.08.005. Epub 2008 Aug 12. Biochem Pharmacol. 2008. PMID: 18761326

10

Modulation of RIP1 ubiquitylation and distribution by MeBS to sensitize cancer cells to tumor necrosis factor α-induced apoptosis.

Kim S, Ohoka N, Okuhira K, Sai K, Nishimaki-Mogami T, Naito M. Kim S, et al. Among authors: okuhira k. Cancer Sci. 2010 Nov;101(11):2425-9. doi: 10.1111/j.1349-7006.2010.01697.x. Cancer Sci. 2010. PMID: 20825417 Free PMC article.

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