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Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.
Rijneveld AW, Weijer S, Florquin S, Esmon CT, Meijers JC, Speelman P, Reitsma PH, Ten Cate H, van der Poll T. Rijneveld AW, et al. Among authors: esmon ct. Blood. 2004 Mar 1;103(5):1702-9. doi: 10.1182/blood-2002-05-1380. Epub 2003 Oct 30. Blood. 2004. PMID: 14592828 Free article.
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.
Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B. Madhusudhan T, et al. Among authors: esmon ct. Blood. 2017 Sep 21;130(12):1445-1455. doi: 10.1182/blood-2017-02-767921. Epub 2017 Jul 7. Blood. 2017. PMID: 28687614 Free PMC article.
Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice.
Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. Lopez-Ramirez MA, et al. Among authors: esmon ct. Blood. 2019 Jan 17;133(3):193-204. doi: 10.1182/blood-2018-06-856062. Epub 2018 Nov 15. Blood. 2019. PMID: 30442679 Free PMC article.
Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1.
Kondreddy V, Wang J, Keshava S, Esmon CT, Rao LVM, Pendurthi UR. Kondreddy V, et al. Among authors: esmon ct. Blood. 2018 May 24;131(21):2379-2392. doi: 10.1182/blood-2017-10-813527. Epub 2018 Apr 18. Blood. 2018. PMID: 29669778 Free PMC article.
398 results