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The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro.
Christov PP, Chowdhury G, Garmendia CA, Wang F, Stover JS, Elmquist CE, Kozekova A, Angel KC, Turesky RJ, Stone MP, Guengerich FP, Rizzo CJ. Christov PP, et al. Among authors: chowdhury g. Chem Res Toxicol. 2010 Jun 21;23(6):1076-88. doi: 10.1021/tx100053n. Chem Res Toxicol. 2010. PMID: 20377178 Free PMC article.
Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site.
Choi JY, Stover JS, Angel KC, Chowdhury G, Rizzo CJ, Guengerich FP. Choi JY, et al. Among authors: chowdhury g. J Biol Chem. 2006 Sep 1;281(35):25297-306. doi: 10.1074/jbc.M605699200. Epub 2006 Jul 10. J Biol Chem. 2006. PMID: 16835218 Free article.
199 results