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Page 1
Synthesis and in vitro and in vivo antifungal activity of the hydroxy metabolites of saperconazole.
Meerpoel L, Heeres J, Backx LJ, Van der Veken LJ, Hendrickx R, Corens D, De Groot A, Leurs S, Van der Eycken L, Weerts J, Luyts P, Van Gerven F, Woestenborghs FA, Van Breda A, Oris M, van Dorsselaer P, Willemsens GH, Bellens D, Marichal PJ, Vanden Bossche HF, Odds FC. Meerpoel L, et al. Among authors: de groot a. ChemMedChem. 2010 May 3;5(5):757-69. doi: 10.1002/cmdc.201000040. ChemMedChem. 2010. PMID: 20379992
Synthesis and in vitro and in vivo structure-activity relationships of novel antifungal triazoles for dermatology.
Meerpoel L, Backx LJ, Van der Veken LJ, Heeres J, Corens D, De Groot A, Odds FC, Van Gerven F, Woestenborghs FA, Van Breda A, Oris M, van Dorsselaer P, Willemsens GH, Vermuyten KJ, Marichal PJ, Vanden Bossche HF, Ausma J, Borgers M. Meerpoel L, et al. Among authors: de groot a. J Med Chem. 2005 Mar 24;48(6):2184-93. doi: 10.1021/jm0494772. J Med Chem. 2005. PMID: 15771461
Synthesis and biological evaluation of 1,2,4-triazinylphenylalkylthiazolecarboxylic acid esters as cytokine-inhibiting antedrugs with strong bronchodilating effects in an animal model of asthma.
Freyne EJ, Lacrampe JF, Deroose F, Boeckx GM, Willems M, Embrechts W, Coesemans E, Willems JJ, Fortin JM, Ligney Y, Dillen LL, Cools WF, Goossens J, Corens D, De Groot A, Van Wauwe JP. Freyne EJ, et al. Among authors: de groot a. J Med Chem. 2005 Mar 24;48(6):2167-75. doi: 10.1021/jm049479m. J Med Chem. 2005. PMID: 15771459
Synthesis and evaluation of novel HCV replication inhibitors.
McGowan DC, Khamlichi MD, De Groot A, Pauwels F, Delouvroy F, Van Emelen K, Simmen K, Raboisson P. McGowan DC, et al. Among authors: de groot a. Mol Divers. 2017 May;21(2):475-481. doi: 10.1007/s11030-017-9733-z. Epub 2017 Mar 14. Mol Divers. 2017. PMID: 28293834
Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches.
Rombouts FJR, Alexander R, Cleiren E, De Groot A, Carpentier M, Dijkmans J, Fierens K, Masure S, Moechars D, Palomino-Schätzlein M, Pineda-Lucena A, Trabanco AA, Van Glabbeek D, Vos A, Tresadern G. Rombouts FJR, et al. Among authors: de groot a. ACS Omega. 2017 Feb 28;2(2):685-697. doi: 10.1021/acsomega.6b00482. Epub 2017 Feb 24. ACS Omega. 2017. PMID: 28626832 Free PMC article.
Automated high-throughput RP-HPLC-MS and SFC-MS analytical and purification platforms to support drug discovery.
Chen K, Dores-Sousa JL, Fontana A, Grosanu C, McAllister HM, Bai G, Bartkowiak K, Cañellas S, Corens D, De Groot A, Nevarez J, Serrano M, Raeymaekers K, Rodriguez R, Van Eynde L, Zhou R, Shi Z. Chen K, et al. Among authors: de groot a. J Chromatogr A. 2024 Dec 31;1742:465648. doi: 10.1016/j.chroma.2024.465648. Online ahead of print. J Chromatogr A. 2024. PMID: 39793447
823 results