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Page 1
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.
Stocking EM, Aluisio L, Atack JR, Bonaventure P, Carruthers NI, Dugovic C, Everson A, Fraser I, Jiang X, Leung P, Lord B, Ly KS, Morton KL, Nepomuceno D, Shah CR, Shelton J, Soyode-Johnson A, Letavic MA. Stocking EM, et al. Among authors: leung p. Bioorg Med Chem Lett. 2010 May 1;20(9):2755-60. doi: 10.1016/j.bmcl.2010.03.071. Epub 2010 Mar 20. Bioorg Med Chem Lett. 2010. PMID: 20382018
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Letavic MA, Aluisio L, Atack JR, Bonaventure P, Carruthers NI, Dugovic C, Everson A, Feinstein MA, Fraser IC, Hoey K, Jiang X, Keith JM, Koudriakova T, Leung P, Lord B, Lovenberg TW, Ly KS, Morton KL, Motley ST, Nepomuceno D, Rizzolio M, Rynberg R, Sepassi K, Shelton J. Letavic MA, et al. Among authors: leung p. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4. doi: 10.1016/j.bmcl.2010.05.041. Epub 2010 May 16. Bioorg Med Chem Lett. 2010. PMID: 20561786
Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8.
Ravula S, Savall BM, Wu N, Lord B, Coe K, Wang K, Seierstad M, Swanson DM, Ziff J, Nguyen M, Leung P, Rynberg R, La D, Pippel DJ, Koudriakova T, Lovenberg TW, Carruthers NI, Maher MP, Ameriks MK. Ravula S, et al. Among authors: leung p. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826. doi: 10.1021/acsmedchemlett.8b00215. eCollection 2018 Aug 9. ACS Med Chem Lett. 2018. PMID: 30128074 Free PMC article.
Structure-function analysis of urotensin II and its use in the construction of a ligand-receptor working model.
Kinney WA, Almond HR Jr, Qi J, Smith CE, Santulli RJ, de Garavilla L, Andrade-Gordon P, Cho DS, Everson AM, Feinstein MA, Leung PA, Maryanoff BE. Kinney WA, et al. Among authors: leung pa. Angew Chem Int Ed Engl. 2002 Aug 16;41(16):2940-4. doi: 10.1002/1521-3773(20020816)41:16<2940::AID-ANIE2940>3.0.CO;2-M. Angew Chem Int Ed Engl. 2002. PMID: 12203418 No abstract available.
Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human.
Coe KJ, Feinstein M, Higgins JW, Leung P, Scott BP, Skaptason J, Tam Y, Volak LP, Kinong J, Bittner A, McAllister H, Lim NM, Hack M, Koudriakova T. Coe KJ, et al. Among authors: leung p. Drug Metab Dispos. 2022 Aug;50(8):1064-1076. doi: 10.1124/dmd.121.000825. Epub 2022 Jun 9. Drug Metab Dispos. 2022. PMID: 35680134
Hypovolaemic phlebotomy in patients undergoing hepatic resection at higher risk of blood loss (PRICE-2): a randomised controlled trial.
Martel G, Carrier FM, Wherrett C, Lenet T, Mallette K, Brousseau K, Monette L, Workneh A, Ruel M, Sabri E, Maddison H, Tokessy M, Wong PBY, Vandenbroucke-Menu F, Massicotte L, Chassé M, Collin Y, Perrault MA, Hamel-Perreault É, Park J, Lim S, Maltais V, Leung P, Gilbert RWD, Segedi M, Khalil JA, Bertens KA, Balaa FK, Ramsay T, Tinmouth A, Fergusson DA. Martel G, et al. Among authors: leung p. Lancet Gastroenterol Hepatol. 2024 Dec 9:S2468-1253(24)00307-8. doi: 10.1016/S2468-1253(24)00307-8. Online ahead of print. Lancet Gastroenterol Hepatol. 2024. PMID: 39667380
A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders.
Di Forti M, Bond BW, Spinazzola E, Trotta G, Lynn J, Malkin R, Kamran Siddiqui N, Demir S, Opadokun T, Leung PBM, Li Z, Quattrone A, Baxter G, Appiah-Kusi E, Freeman TP, Walsh H, Squeri T, Semikina D, Amberson-Jones F, Austin-Zimmerman I, Meynen T, Quattrone D, Murray RM. Di Forti M, et al. Among authors: leung pbm. BJPsych Open. 2024 Dec 12;11(1):e1. doi: 10.1192/bjo.2024.782. BJPsych Open. 2024. PMID: 39663754 Free article.
2,632 results