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1,185 results

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Page 1
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.
Baur F, Beattie D, Beer D, Bentley D, Bradley M, Bruce I, Charlton SJ, Cuenoud B, Ernst R, Fairhurst RA, Faller B, Farr D, Keller T, Fozard JR, Fullerton J, Garman S, Hatto J, Hayden C, He H, Howes C, Janus D, Jiang Z, Lewis C, Loeuillet-Ritzler F, Moser H, Reilly J, Steward A, Sykes D, Tedaldi L, Trifilieff A, Tweed M, Watson S, Wissler E, Wyss D. Baur F, et al. Among authors: keller t. J Med Chem. 2010 May 13;53(9):3675-84. doi: 10.1021/jm100068m. J Med Chem. 2010. PMID: 20402514
Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters.
Sandham DA, Barker L, Beattie D, Beer D, Bidlake L, Bentley D, Butler KD, Craig S, Farr D, Ffoulkes-Jones C, Fozard JR, Haberthuer S, Howes C, Hynx D, Jeffers S, Keller TH, Kirkham PA, Maas JC, Mazzoni L, Nicholls A, Pilgrim GE, Schaebulin E, Spooner GM, Stringer R, Tranter P, Turner KL, Tweed MF, Walker C, Watson SJ, Cuenoud BM. Sandham DA, et al. Bioorg Med Chem. 2004 Oct 1;12(19):5213-24. doi: 10.1016/j.bmc.2004.06.027. Bioorg Med Chem. 2004. PMID: 15351404
New highly potent and selective adenosine A(3) receptor antagonists.
Press NJ, Keller TH, Tranter P, Beer D, Jones K, Faessler A, Heng R, Lewis C, Howe T, Gedeck P, Mazzoni L, Fozard JR. Press NJ, et al. Among authors: keller th. Curr Top Med Chem. 2004;4(8):863-70. doi: 10.2174/1568026043451023. Curr Top Med Chem. 2004. PMID: 15078217
Potent and selective xanthine-based inhibitors of phosphodiesterase 5.
Arnold NJ, Arnold R, Beer D, Bhalay G, Collingwood SP, Craig S, Devereux N, Dodds M, Dunstan AR, Fairhurst RA, Farr D, Fullerton JD, Glen A, Gomez S, Haberthuer S, Hatto JD, Howes C, Jones D, Keller TH, Leuenberger B, Moser HE, Muller I, Naef R, Nicklin PA, Sandham DA, Turner KL, Tweed MF, Watson SJ, Zurini M. Arnold NJ, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2376-9. doi: 10.1016/j.bmcl.2006.11.019. Epub 2006 Nov 10. Bioorg Med Chem Lett. 2007. PMID: 17337182
Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Arnold N, Beer D, Brown L, Cheung R, Christie J, Denholm A, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Oakman H, Sahri H, Tuffnell AR, Tweed M, Tyler JW, Wagner T, Fozard JR, Trifilieff A. Press NJ, et al. Among authors: keller th. J Med Chem. 2012 Sep 13;55(17):7472-9. doi: 10.1021/jm300459a. Epub 2012 Aug 30. J Med Chem. 2012. PMID: 22889281
Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).
Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Arnold N, Beer D, Brown L, Cheung R, Christie J, Denholm A, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Oakman H, Sahri H, Tuffnell AR, Tweed M, Trifilieff A. Press NJ, et al. J Med Chem. 2015 Sep 10;58(17):6747-52. doi: 10.1021/acs.jmedchem.5b00902. Epub 2015 Aug 28. J Med Chem. 2015. PMID: 26288344
Design and synthesis of a library of chemokine antagonists.
Bhalay G, Albrecht B, Akhlaq M, Baettig U, Beer D, Brown Z, Charlton S, Dunstan A, Bradley M, Gedeck P, Glen A, Howe T, Keller T, Leighton-Davies J, Li A, McCarthy C, Mocquet C, Owen C, Nicklin P, Rosethorne E. Bhalay G, et al. Among authors: keller t. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6249-52. doi: 10.1016/j.bmcl.2011.09.013. Epub 2011 Sep 10. Bioorg Med Chem Lett. 2011. PMID: 21940167
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.
Bruce I, Akhlaq M, Bloomfield GC, Budd E, Cox B, Cuenoud B, Finan P, Gedeck P, Hatto J, Hayler JF, Head D, Keller T, Kirman L, Leblanc C, Le Grand D, McCarthy C, O'Connor D, Owen C, Oza MS, Pilgrim G, Press NE, Sviridenko L, Whitehead L. Bruce I, et al. Among authors: keller t. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5445-50. doi: 10.1016/j.bmcl.2012.07.042. Epub 2012 Jul 17. Bioorg Med Chem Lett. 2012. PMID: 22863202
1,185 results