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A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.
Ho AJ, Stein JL, Hua X, Lee S, Hibar DP, Leow AD, Dinov ID, Toga AW, Saykin AJ, Shen L, Foroud T, Pankratz N, Huentelman MJ, Craig DW, Gerber JD, Allen AN, Corneveaux JJ, Stephan DA, DeCarli CS, DeChairo BM, Potkin SG, Jack CR Jr, Weiner MW, Raji CA, Lopez OL, Becker JT, Carmichael OT, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. Ho AJ, et al. Among authors: hua x. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8404-9. doi: 10.1073/pnas.0910878107. Epub 2010 Apr 19. Proc Natl Acad Sci U S A. 2010. PMID: 20404173 Free PMC article.
Obesity is linked with lower brain volume in 700 AD and MCI patients.
Ho AJ, Raji CA, Becker JT, Lopez OL, Kuller LH, Hua X, Lee S, Hibar D, Dinov ID, Stein JL, Jack CR Jr, Weiner MW, Toga AW, Thompson PM; Cardiovascular Health Study; ADNI. Ho AJ, et al. Among authors: hua x. Neurobiol Aging. 2010 Aug;31(8):1326-39. doi: 10.1016/j.neurobiolaging.2010.04.006. Epub 2010 Jun 8. Neurobiol Aging. 2010. PMID: 20570405 Free PMC article.
Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.
Jahanshad N, Rajagopalan P, Hua X, Hibar DP, Nir TM, Toga AW, Jack CR Jr, Saykin AJ, Green RC, Weiner MW, Medland SE, Montgomery GW, Hansell NK, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Thompson PM; Alzheimer’s Disease Neuroimaging Initiative. Jahanshad N, et al. Among authors: hua x. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4768-73. doi: 10.1073/pnas.1216206110. Epub 2013 Mar 5. Proc Natl Acad Sci U S A. 2013. PMID: 23471985 Free PMC article. Clinical Trial.
3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry.
Hua X, Leow AD, Lee S, Klunder AD, Toga AW, Lepore N, Chou YY, Brun C, Chiang MC, Barysheva M, Jack CR Jr, Bernstein MA, Britson PJ, Ward CP, Whitwell JL, Borowski B, Fleisher AS, Fox NC, Boyes RG, Barnes J, Harvey D, Kornak J, Schuff N, Boreta L, Alexander GE, Weiner MW, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. Hua X, et al. Neuroimage. 2008 May 15;41(1):19-34. doi: 10.1016/j.neuroimage.2008.02.010. Epub 2008 Feb 21. Neuroimage. 2008. PMID: 18378167 Free PMC article.
Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease mild cognitive impairment, and elderly controls.
Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR Jr, Weiner MW, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. Morra JH, et al. Among authors: hua x. Neuroimage. 2008 Oct 15;43(1):59-68. doi: 10.1016/j.neuroimage.2008.07.003. Epub 2008 Jul 16. Neuroimage. 2008. PMID: 18675918 Free PMC article.
Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.
Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR Jr, Schuff N, Weiner MW, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. Morra JH, et al. Among authors: hua x. Hum Brain Mapp. 2009 Sep;30(9):2766-88. doi: 10.1002/hbm.20708. Hum Brain Mapp. 2009. PMID: 19172649 Free PMC article.
2,748 results