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Page 1
Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands.
Peters JU, Hoffmann T, Schnider P, Stadler H, Koblet A, Alker A, Poli SM, Ballard TM, Spooren W, Steward L, Sleight AJ. Peters JU, et al. Among authors: ballard tm. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3405-8. doi: 10.1016/j.bmcl.2010.04.008. Epub 2010 Apr 9. Bioorg Med Chem Lett. 2010. PMID: 20430616
Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.
Jaeschke G, Porter R, Büttelmann B, Ceccarelli SM, Guba W, Kuhn B, Kolczewski S, Huwyler J, Mutel V, Peters JU, Ballard T, Prinssen E, Vieira E, Wichmann J, Spooren W. Jaeschke G, et al. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1307-11. doi: 10.1016/j.bmcl.2006.12.033. Epub 2006 Dec 15. Bioorg Med Chem Lett. 2007. PMID: 17196387
The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.
Knust H, Achermann G, Ballard T, Buettelmann B, Gasser R, Fischer H, Hernandez MC, Knoflach F, Koblet A, Stadler H, Thomas AW, Trube G, Waldmeier P. Knust H, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. doi: 10.1016/j.bmcl.2009.08.053. Epub 2009 Aug 15. Bioorg Med Chem Lett. 2009. PMID: 19762240
Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.
Achermann G, Ballard TM, Blasco F, Broutin PE, Büttelmann B, Fischer H, Graf M, Hernandez MC, Hilty P, Knoflach F, Koblet A, Knust H, Kurt A, Martin JR, Masciadri R, Porter RH, Stadler H, Thomas AW, Trube G, Wichmann J. Achermann G, et al. Among authors: ballard tm. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5746-52. doi: 10.1016/j.bmcl.2009.07.153. Epub 2009 Aug 4. Bioorg Med Chem Lett. 2009. PMID: 19726184
Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA alpha5 inverse agonists with potential for the treatment of cognitive dysfunction.
Buettelmann B, Ballard TM, Gasser R, Fischer H, Hernandez MC, Knoflach F, Knust H, Stadler H, Thomas AW, Trube G. Buettelmann B, et al. Among authors: ballard tm. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5958-61. doi: 10.1016/j.bmcl.2009.08.027. Epub 2009 Aug 11. Bioorg Med Chem Lett. 2009. PMID: 19740657
56 results