Dent P - Search Results

1

17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species.

Walker T, Mitchell C, Park MA, Yacoub A, Rahmani M, Häussinger D, Reinehr R, Voelkel-Johnson C, Fisher PB, Grant S, Dent P. Walker T, et al. Among authors: dent p. Mol Cancer Ther. 2010 May;9(5):1378-95. doi: 10.1158/1535-7163.MCT-09-1131. Epub 2010 May 4. Mol Cancer Ther. 2010. PMID: 20442308 Free PMC article.

2

Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms.

Qiao L, Yacoub A, McKinstry R, Park JS, Caron R, Fisher PB, Hagan MP, Grant S, Dent P. Qiao L, et al. Among authors: dent p. Cancer Biol Ther. 2002 Mar-Apr;1(2):168-76. doi: 10.4161/cbt.64. Cancer Biol Ther. 2002. PMID: 12170777 Free article.

3

The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.

Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, Grant S. Yu C, et al. Among authors: dent p. Cancer Res. 2003 Apr 15;63(8):1822-33. Cancer Res. 2003. PMID: 12702569

4

MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.

Yacoub A, Mitchell C, Brannon J, Rosenberg E, Qiao L, McKinstry R, Linehan WM, Su ZS, Sarkar D, Lebedeva IV, Valerie K, Gopalkrishnan RV, Grant S, Fisher PB, Dent P. Yacoub A, et al. Among authors: dent p. Mol Cancer Ther. 2003 Jul;2(7):623-32. Mol Cancer Ther. 2003. PMID: 12883035

5

Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.

Rahmani M, Yu C, Dai Y, Reese E, Ahmed W, Dent P, Grant S. Rahmani M, et al. Among authors: dent p. Cancer Res. 2003 Dec 1;63(23):8420-7. Cancer Res. 2003. PMID: 14679005

6

Sequence dependent exposure of mammary carcinoma cells to Taxotere and the MEK1/2 inhibitor U0126 causes enhanced cell killing in vitro.

Yacoub A, Han SI, Caron R, Gilfor D, Mooberry S, Grant S, Dent P. Yacoub A, et al. Among authors: dent p. Cancer Biol Ther. 2003 Nov-Dec;2(6):670-6. Cancer Biol Ther. 2003. PMID: 14688474

7

Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: what's in a name?

Grant S, Dent P. Grant S, et al. Among authors: dent p. Mol Cancer Ther. 2004 Jul;3(7):873-5. Mol Cancer Ther. 2004. PMID: 15252148 Review. No abstract available.

8

Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change.

Rahmani M, Reese E, Dai Y, Bauer C, Kramer LB, Huang M, Jove R, Dent P, Grant S. Rahmani M, et al. Among authors: dent p. Mol Pharmacol. 2005 Apr;67(4):1166-76. doi: 10.1124/mol.104.007831. Epub 2004 Dec 29. Mol Pharmacol. 2005. PMID: 15625278

9

H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.

Carón RW, Yacoub A, Zhu X, Mitchell C, Han SI, Sasazuki T, Shirasawa S, Hagan MP, Grant S, Dent P. Carón RW, et al. Among authors: dent p. Mol Cancer Ther. 2005 Feb;4(2):243-55. Mol Cancer Ther. 2005. PMID: 15713896

10

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

Carón RW, Yacoub A, Li M, Zhu X, Mitchell C, Hong Y, Hawkins W, Sasazuki T, Shirasawa S, Kozikowski AP, Dennis PA, Hagan MP, Grant S, Dent P. Carón RW, et al. Among authors: dent p. Mol Cancer Ther. 2005 Feb;4(2):257-70. Mol Cancer Ther. 2005. PMID: 15713897

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