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Page 1
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Kalender A, Selvaraj A, Kim SY, Gulati P, Brûlé S, Viollet B, Kemp BE, Bardeesy N, Dennis P, Schlager JJ, Marette A, Kozma SC, Thomas G. Kalender A, et al. Among authors: kozma sc. Cell Metab. 2010 May 5;11(5):390-401. doi: 10.1016/j.cmet.2010.03.014. Cell Metab. 2010. PMID: 20444419 Free PMC article.
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.
Gulati P, Gaspers LD, Dann SG, Joaquin M, Nobukuni T, Natt F, Kozma SC, Thomas AP, Thomas G. Gulati P, et al. Among authors: kozma sc. Cell Metab. 2008 May;7(5):456-65. doi: 10.1016/j.cmet.2008.03.002. Cell Metab. 2008. PMID: 18460336 Free PMC article.
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.
Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Thomas G, Sonenberg N. Dowling RJ, et al. Among authors: kozma sc. Science. 2010 May 28;328(5982):1172-6. doi: 10.1126/science.1187532. Science. 2010. PMID: 20508131 Free PMC article.
A liaison between mTOR signaling, ribosome biogenesis and cancer.
Gentilella A, Kozma SC, Thomas G. Gentilella A, et al. Among authors: kozma sc. Biochim Biophys Acta. 2015 Jul;1849(7):812-20. doi: 10.1016/j.bbagrm.2015.02.005. Epub 2015 Feb 28. Biochim Biophys Acta. 2015. PMID: 25735853 Free PMC article. Review.
Mitochondrial Complex I Activity Is Required for Maximal Autophagy.
Thomas HE, Zhang Y, Stefely JA, Veiga SR, Thomas G, Kozma SC, Mercer CA. Thomas HE, et al. Among authors: kozma sc. Cell Rep. 2018 Aug 28;24(9):2404-2417.e8. doi: 10.1016/j.celrep.2018.07.101. Cell Rep. 2018. PMID: 30157433 Free PMC article.
Hypothalamic mTOR signaling regulates food intake.
Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ. Cota D, et al. Among authors: kozma sc. Science. 2006 May 12;312(5775):927-30. doi: 10.1126/science.1124147. Science. 2006. PMID: 16690869
S6K1 plays a critical role in early adipocyte differentiation.
Carnevalli LS, Masuda K, Frigerio F, Le Bacquer O, Um SH, Gandin V, Topisirovic I, Sonenberg N, Thomas G, Kozma SC. Carnevalli LS, et al. Among authors: kozma sc. Dev Cell. 2010 May 18;18(5):763-74. doi: 10.1016/j.devcel.2010.02.018. Dev Cell. 2010. PMID: 20493810 Free PMC article.
98 results