Martínez-García E - Search Results

1

Repetitive nicotine exposure leads to a more malignant and metastasis-prone phenotype of SCLC: a molecular insight into the importance of quitting smoking during treatment.

Martínez-García E, Irigoyen M, González-Moreno O, Corrales L, Teijeira A, Salvo E, Rouzaut A. Martínez-García E, et al. Toxicol Sci. 2010 Aug;116(2):467-76. doi: 10.1093/toxsci/kfq138. Epub 2010 May 10. Toxicol Sci. 2010. PMID: 20457658 Free article.

2

Recurrent exposure to nicotine differentiates human bronchial epithelial cells via epidermal growth factor receptor activation.

Martínez-García E, Irigoyen M, Ansó E, Martínez-Irujo JJ, Rouzaut A. Martínez-García E, et al. Toxicol Appl Pharmacol. 2008 May 1;228(3):334-42. doi: 10.1016/j.taap.2007.12.016. Epub 2007 Dec 23. Toxicol Appl Pharmacol. 2008. PMID: 18262213 Free article.

3

MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents.

Shah MY, Martinez-Garcia E, Phillip JM, Chambliss AB, Popovic R, Ezponda T, Small EC, Will C, Phillip MP, Neri P, Bahlis NJ, Wirtz D, Licht JD. Shah MY, et al. Oncogene. 2016 Nov 10;35(45):5905-5915. doi: 10.1038/onc.2016.116. Epub 2016 Apr 25. Oncogene. 2016. PMID: 27109101 Free PMC article.

4

The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer.

Ezponda T, Popovic R, Shah MY, Martinez-Garcia E, Zheng Y, Min DJ, Will C, Neri A, Kelleher NL, Yu J, Licht JD. Ezponda T, et al. Oncogene. 2013 Jun 6;32(23):2882-90. doi: 10.1038/onc.2012.297. Epub 2012 Jul 16. Oncogene. 2013. PMID: 22797064 Free PMC article.

5

MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC.

Min DJ, Ezponda T, Kim MK, Will CM, Martinez-Garcia E, Popovic R, Basrur V, Elenitoba-Johnson KS, Licht JD. Min DJ, et al. Leukemia. 2013 Mar;27(3):686-94. doi: 10.1038/leu.2012.269. Epub 2012 Sep 13. Leukemia. 2013. PMID: 22972034 Free PMC article.

6

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD. Martinez-Garcia E, et al. Blood. 2011 Jan 6;117(1):211-20. doi: 10.1182/blood-2010-07-298349. Epub 2010 Oct 25. Blood. 2011. PMID: 20974671 Free PMC article.

7

Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3.

Zheng Y, Sweet SM, Popovic R, Martinez-Garcia E, Tipton JD, Thomas PM, Licht JD, Kelleher NL. Zheng Y, et al. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13549-54. doi: 10.1073/pnas.1205707109. Epub 2012 Aug 6. Proc Natl Acad Sci U S A. 2012. PMID: 22869745 Free PMC article.

8

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.

Popovic R, Martinez-Garcia E, Giannopoulou EG, Zhang Q, Zhang Q, Ezponda T, Shah MY, Zheng Y, Will CM, Small EC, Hua Y, Bulic M, Jiang Y, Carrara M, Calogero RA, Kath WL, Kelleher NL, Wang JP, Elemento O, Licht JD. Popovic R, et al. PLoS Genet. 2014 Sep 4;10(9):e1004566. doi: 10.1371/journal.pgen.1004566. eCollection 2014 Sep. PLoS Genet. 2014. PMID: 25188243 Free PMC article.

9

Deregulation of H3K27 methylation in cancer.

Martinez-Garcia E, Licht JD. Martinez-Garcia E, et al. Nat Genet. 2010 Feb;42(2):100-1. doi: 10.1038/ng0210-100. Nat Genet. 2010. PMID: 20104248

10

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

Sullivan LB, Martinez-Garcia E, Nguyen H, Mullen AR, Dufour E, Sudarshan S, Licht JD, Deberardinis RJ, Chandel NS. Sullivan LB, et al. Mol Cell. 2013 Jul 25;51(2):236-48. doi: 10.1016/j.molcel.2013.05.003. Epub 2013 Jun 6. Mol Cell. 2013. PMID: 23747014 Free PMC article.

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