Patton JT - Search Results

1

GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.

Chang J, Patton JT, Sarkar A, Ernst B, Magnani JL, Frenette PS. Chang J, et al. Among authors: patton jt. Blood. 2010 Sep 9;116(10):1779-86. doi: 10.1182/blood-2009-12-260513. Epub 2010 May 27. Blood. 2010. PMID: 20508165 Free PMC article.

2

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.

Azab AK, Quang P, Azab F, Pitsillides C, Thompson B, Chonghaile T, Patton JT, Maiso P, Monrose V, Sacco A, Ngo HT, Flores LM, Lin CP, Magnani JL, Kung AL, Letai A, Carrasco R, Roccaro AM, Ghobrial IM. Azab AK, et al. Among authors: patton jt. Blood. 2012 Feb 9;119(6):1468-78. doi: 10.1182/blood-2011-07-368050. Epub 2011 Nov 16. Blood. 2012. PMID: 22096244 Free PMC article.

3

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance.

Winkler IG, Barbier V, Nowlan B, Jacobsen RN, Forristal CE, Patton JT, Magnani JL, Lévesque JP. Winkler IG, et al. Among authors: patton jt. Nat Med. 2012 Nov;18(11):1651-7. doi: 10.1038/nm.2969. Epub 2012 Oct 21. Nat Med. 2012. PMID: 23086476

4

Synthesis and biological evaluation of a potent E-selectin antagonist.

Thoma G, Kinzy W, Bruns C, Patton JT, Magnani JL, Bänteli R. Thoma G, et al. Among authors: patton jt. J Med Chem. 1999 Nov 18;42(23):4909-13. doi: 10.1021/jm990422n. J Med Chem. 1999. PMID: 10579852

5

Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists?

Titz A, Patton J, Alker AM, Porro M, Schwardt O, Hennig M, Francotte E, Magnani J, Ernst B. Titz A, et al. Bioorg Med Chem. 2008 Jan 15;16(2):1046-56. doi: 10.1016/j.bmc.2007.07.025. Epub 2007 Aug 22. Bioorg Med Chem. 2008. PMID: 17845854

6

Probing the carbohydrate recognition domain of E-selectin: the importance of the acid orientation in sLex mimetics.

Titz A, Patton J, Smiesko M, Radic Z, Schwardt O, Magnani JL, Ernst B. Titz A, et al. Bioorg Med Chem. 2010 Jan 1;18(1):19-27. doi: 10.1016/j.bmc.2009.11.024. Epub 2009 Nov 13. Bioorg Med Chem. 2010. PMID: 19948406

7

Pre-organization of the core structure of E-selectin antagonists.

Schwizer D, Patton JT, Cutting B, Smieško M, Wagner B, Kato A, Weckerle C, Binder FP, Rabbani S, Schwardt O, Magnani JL, Ernst B. Schwizer D, et al. Among authors: patton jt. Chemistry. 2012 Jan 27;18(5):1342-51. doi: 10.1002/chem.201102884. Epub 2011 Dec 30. Chemistry. 2012. PMID: 22213563

8

A Readily Available, Highly Potent E-Selectin Antagonist.

Thoma G, Bänteli R, Jahnke W, Magnani JL, Patton JT. Thoma G, et al. Among authors: patton jt. Angew Chem Int Ed Engl. 2001 Oct 1;40(19):3644-3647. doi: 10.1002/1521-3773(20011001)40:19<3644::AID-ANIE3644>3.0.CO;2-S. Angew Chem Int Ed Engl. 2001. PMID: 11592208 No abstract available.

9

Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition.

Thoma G, Magnani JL, Patton JT. Thoma G, et al. Among authors: patton jt. Bioorg Med Chem Lett. 2001 Apr 9;11(7):923-5. doi: 10.1016/s0960-894x(01)00092-0. Bioorg Med Chem Lett. 2001. PMID: 11294392

10

Preorganization of the Bioactive Conformation of Sialyl Lewis(X) Analogues Correlates with Their Affinity to E-Selectin.

Thoma G, Magnani JL, Patton JT, Ernst B, Jahnke W. Thoma G, et al. Among authors: patton jt. Angew Chem Int Ed Engl. 2001 May 18;40(10):1941-1945. Angew Chem Int Ed Engl. 2001. PMID: 11385680 No abstract available.

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