Graham IR - Search Results

1

Transcriptomic analysis of dystrophin RNAi knockdown reveals a central role for dystrophin in muscle differentiation and contractile apparatus organization.

Ghahramani Seno MM, Trollet C, Athanasopoulos T, Graham IR, Hu P, Dickson G. Ghahramani Seno MM, et al. Among authors: graham ir. BMC Genomics. 2010 Jun 1;11:345. doi: 10.1186/1471-2164-11-345. BMC Genomics. 2010. PMID: 20515474 Free PMC article.

2

RNAi-mediated knockdown of dystrophin expression in adult mice does not lead to overt muscular dystrophy pathology.

Ghahramani Seno MM, Graham IR, Athanasopoulos T, Trollet C, Pohlschmidt M, Crompton MR, Dickson G. Ghahramani Seno MM, et al. Among authors: graham ir. Hum Mol Genet. 2008 Sep 1;17(17):2622-32. doi: 10.1093/hmg/ddn162. Epub 2008 May 28. Hum Mol Genet. 2008. PMID: 18511456

3

Recombinant adeno-associated viral (rAAV) vectors as therapeutic tools for Duchenne muscular dystrophy (DMD).

Athanasopoulos T, Graham IR, Foster H, Dickson G. Athanasopoulos T, et al. Among authors: graham ir. Gene Ther. 2004 Oct;11 Suppl 1:S109-21. doi: 10.1038/sj.gt.3302379. Gene Ther. 2004. PMID: 15454965 Review.

4

Stable micro-dystrophin gene transfer using an integrating adeno-retroviral hybrid vector ameliorates the dystrophic pathology in mdx mouse muscle.

Roberts ML, Wells DJ, Graham IR, Fabb SA, Hill VJ, Duisit G, Yuasa K, Takeda S, Cosset FL, Dickson G. Roberts ML, et al. Among authors: graham ir. Hum Mol Genet. 2002 Jul 15;11(15):1719-30. doi: 10.1093/hmg/11.15.1719. Hum Mol Genet. 2002. PMID: 12095914

5

Towards a therapeutic inhibition of dystrophin exon 23 splicing in mdx mouse muscle induced by antisense oligoribonucleotides (splicomers): target sequence optimisation using oligonucleotide arrays.

Graham IR, Hill VJ, Manoharan M, Inamati GB, Dickson G. Graham IR, et al. J Gene Med. 2004 Oct;6(10):1149-58. doi: 10.1002/jgm.603. J Gene Med. 2004. PMID: 15386737

6

Human apolipoprotein E expression from mouse skeletal muscle by electrotransfer of nonviral DNA (plasmid) and pseudotyped recombinant adeno-associated virus (AAV2/7).

Evans V, Foster H, Graham IR, Foster K, Athanasopoulos T, Simons JP, Dickson G, Owen JS. Evans V, et al. Among authors: graham ir. Hum Gene Ther. 2008 Jun;19(6):569-78. doi: 10.1089/hum.2007.169. Hum Gene Ther. 2008. PMID: 18578629

7

Codon and mRNA sequence optimization of microdystrophin transgenes improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer.

Foster H, Sharp PS, Athanasopoulos T, Trollet C, Graham IR, Foster K, Wells DJ, Dickson G. Foster H, et al. Among authors: graham ir. Mol Ther. 2008 Nov;16(11):1825-32. doi: 10.1038/mt.2008.186. Epub 2008 Sep 2. Mol Ther. 2008. PMID: 18766174 Free article.

8

Design of phosphorodiamidate morpholino oligomers (PMOs) for the induction of exon skipping of the human DMD gene.

Popplewell LJ, Trollet C, Dickson G, Graham IR. Popplewell LJ, et al. Among authors: graham ir. Mol Ther. 2009 Mar;17(3):554-61. doi: 10.1038/mt.2008.287. Epub 2009 Jan 13. Mol Ther. 2009. PMID: 19142179 Free PMC article.

9

Adeno-associated virus-8-mediated intravenous transfer of myostatin propeptide leads to systemic functional improvements of slow but not fast muscle.

Foster K, Graham IR, Otto A, Foster H, Trollet C, Yaworsky PJ, Walsh FS, Bickham D, Curtin NA, Kawar SL, Patel K, Dickson G. Foster K, et al. Among authors: graham ir. Rejuvenation Res. 2009 Apr;12(2):85-94. doi: 10.1089/rej.2008.0815. Rejuvenation Res. 2009. PMID: 19405813

10

Dosing regimen has a significant impact on the efficiency of morpholino oligomer-induced exon skipping in mdx mice.

Malerba A, Thorogood FC, Dickson G, Graham IR. Malerba A, et al. Among authors: graham ir. Hum Gene Ther. 2009 Sep;20(9):955-65. doi: 10.1089/hum.2008.157. Hum Gene Ther. 2009. PMID: 19469709

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