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CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity.
Briceño P, Rivas-Yañez E, Rosemblatt MV, Parra-Tello B, Farías P, Vargas L, Simon V, Cárdenas C, Lladser A, Salazar-Onfray F, Elorza AA, Rosemblatt M, Bono MR, Sauma D. Briceño P, et al. Among authors: farias p. Front Cell Dev Biol. 2021 Feb 18;9:638037. doi: 10.3389/fcell.2021.638037. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33681221 Free PMC article.
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival.
Cardenas C, Lovy A, Silva-Pavez E, Urra F, Mizzoni C, Ahumada-Castro U, Bustos G, Jaňa F, Cruz P, Farias P, Mendoza E, Huerta H, Murgas P, Hunter M, Rios M, Cerda O, Georgakoudi I, Zakarian A, Molgó J, Foskett JK. Cardenas C, et al. Among authors: farias p. Sci Signal. 2020 Jul 14;13(640):eaay1212. doi: 10.1126/scisignal.aay1212. Sci Signal. 2020. PMID: 32665411 Free PMC article.
The IP3R inhibitor desmethylxestospongin B reduces tumor cell migration, invasion and metastasis by impairing lysosome acidification and β1-integrin recycling.
Bustos G, Ahumada-Castro U, Silva-Pavez E, Huerta H, Puebla A, Quezada C, Morgado-Cáceres P, Casanova-Canelo C, Smith-Cortinez N, Podunavac M, Oyarce C, Lladser A, Farias P, Lovy A, Molgó J, Torres VA, Zakarian A, Cárdenas JC. Bustos G, et al. Among authors: farias p. Biochim Biophys Acta Mol Basis Dis. 2025 Jan;1871(1):167557. doi: 10.1016/j.bbadis.2024.167557. Epub 2024 Oct 31. Biochim Biophys Acta Mol Basis Dis. 2025. PMID: 39486657 Free PMC article.
194 results