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The synthetic heat shock protein 90 (Hsp90) inhibitor EC141 induces degradation of Bcr-Abl p190 protein and apoptosis of Ph-positive acute lymphoblastic leukemia cells.
Tong WG, Estrov Z, Wang Y, O'Brien S, Faderl S, Harris DM, Van Pham Q, Hazan-Halevy I, Liu Z, Koch P, Kantarjian H, Keating MJ, Ferrajoli A. Tong WG, et al. Among authors: liu z. Invest New Drugs. 2011 Dec;29(6):1206-12. doi: 10.1007/s10637-010-9465-8. Epub 2010 Jun 9. Invest New Drugs. 2011. PMID: 20533075 Free PMC article.
Kit inhibitor APcK110 extends survival in an AML xenograft mouse model.
Faderl S, Bueso-Ramos C, Liu Z, Pal A, Bornmann W, Ciurea DV, Harris D, Hazan-Halevy I, Kantarjian HM, Estrov Z. Faderl S, et al. Among authors: liu z. Invest New Drugs. 2011 Oct;29(5):1094-7. doi: 10.1007/s10637-010-9459-6. Epub 2010 Jun 3. Invest New Drugs. 2011. PMID: 20517635 Free PMC article.
STAT-3 activates NF-kappaB in chronic lymphocytic leukemia cells.
Liu Z, Hazan-Halevy I, Harris DM, Li P, Ferrajoli A, Faderl S, Keating MJ, Estrov Z. Liu Z, et al. Mol Cancer Res. 2011 Apr;9(4):507-15. doi: 10.1158/1541-7786.MCR-10-0559. Epub 2011 Mar 1. Mol Cancer Res. 2011. PMID: 21364020 Free PMC article.
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