Gertsch J - Search Results

1

Catalytic selective cyclizations of aminocyclopropanes: formal synthesis of aspidospermidine and total synthesis of goniomitine.

De Simone F, Gertsch J, Waser J. De Simone F, et al. Among authors: gertsch j. Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5767-70. doi: 10.1002/anie.201001853. Angew Chem Int Ed Engl. 2010. PMID: 20533490 No abstract available.

2

Total synthesis of the marine diterpenoid blumiolide C.

Hamel C, Prusov EV, Gertsch J, Schweizer WB, Altmann KH. Hamel C, et al. Among authors: gertsch j. Angew Chem Int Ed Engl. 2008;47(52):10081-5. doi: 10.1002/anie.200804004. Angew Chem Int Ed Engl. 2008. PMID: 19039812 No abstract available.

3

Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity.

Feyen F, Gertsch J, Wartmann M, Altmann KH. Feyen F, et al. Among authors: gertsch j. Angew Chem Int Ed Engl. 2006 Sep 4;45(35):5880-5. doi: 10.1002/anie.200601359. Angew Chem Int Ed Engl. 2006. PMID: 16871640 No abstract available.

4

Synthesis of (-)-dactylolide and 13-desmethylene-(-)-dactylolide and their effects on tubulin.

Zurwerra D, Gertsch J, Altmann KH. Zurwerra D, et al. Among authors: gertsch j. Org Lett. 2010 May 21;12(10):2302-5. doi: 10.1021/ol100665m. Org Lett. 2010. PMID: 20415434

5

Total synthesis of (-)-zampanolide and structure-activity relationship studies on (-)-dactylolide derivatives.

Zurwerra D, Glaus F, Betschart L, Schuster J, Gertsch J, Ganci W, Altmann KH. Zurwerra D, et al. Among authors: gertsch j. Chemistry. 2012 Dec 21;18(52):16868-83. doi: 10.1002/chem.201202553. Epub 2012 Nov 7. Chemistry. 2012. PMID: 23136113

6

Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity.

Kuzniewski CN, Gertsch J, Wartmann M, Altmann KH. Kuzniewski CN, et al. Among authors: gertsch j. Org Lett. 2008 Mar 20;10(6):1183-6. doi: 10.1021/ol800089x. Epub 2008 Feb 28. Org Lett. 2008. PMID: 18303900

7

Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin.

Leonti M, Casu L, Raduner S, Cottiglia F, Floris C, Altmann KH, Gertsch J. Leonti M, et al. Among authors: gertsch j. Biochem Pharmacol. 2010 Jun 15;79(12):1815-26. doi: 10.1016/j.bcp.2010.02.015. Epub 2010 Mar 3. Biochem Pharmacol. 2010. PMID: 20206138

8

Natural products as leads for anticancer drug discovery: discovery of new chemotypes of microtubule stabilizers through reengineering of the epothilone scaffold.

Altmann KH, Cachoux F, Feyen F, Gertsch J, Kuzniewski CN, Wartmann M. Altmann KH, et al. Among authors: gertsch j. Chimia (Aarau). 2010;64(1-2):8-13. doi: 10.2533/chimia.2010.8. Chimia (Aarau). 2010. PMID: 21137676 Free article.

9

Synthesis and biological activity of new functionalized epothilones for prodrug design and tumor targeting.

Dietrich SA, Riediker L, Gertsch J, Altmann KH. Dietrich SA, et al. Among authors: gertsch j. Chimia (Aarau). 2010;64(3):136-9. doi: 10.2533/chimia.2010.136. Chimia (Aarau). 2010. PMID: 21140905 Free article.

10

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).

Jantsch A, Nieto L, Gertsch J, Rodríguez-Salarichs J, Matesanz R, Jiménez-Barbero J, Díaz JF, Canales Á, Altmann KH. Jantsch A, et al. Among authors: gertsch j. Molecules. 2016 Aug 3;21(8):1010. doi: 10.3390/molecules21081010. Molecules. 2016. PMID: 27527129 Free PMC article.

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