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Page 1
Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.
Nishizawa R, Nishiyama T, Hisaichi K, Hirai K, Habashita H, Takaoka Y, Tada H, Sagawa K, Shibayama S, Maeda K, Mitsuya H, Nakai H, Fukushima D, Toda M. Nishizawa R, et al. Among authors: nishiyama t. Bioorg Med Chem. 2010 Jul 15;18(14):5208-23. doi: 10.1016/j.bmc.2010.05.057. Epub 2010 May 25. Bioorg Med Chem. 2010. PMID: 20542438 Free PMC article.
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.
Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Naka M, Komeno M, Nakai H, Toda M. Kawanaka Y, et al. Among authors: nishiyama t. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2291-4. doi: 10.1016/s0960-894x(02)00455-9. Bioorg Med Chem Lett. 2002. PMID: 12161118
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines.
Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Nishizaki M, Naka M, Komeno M, Nakai H, Toda M. Kawanaka Y, et al. Among authors: nishiyama t. Bioorg Med Chem. 2003 Mar 6;11(5):689-702. doi: 10.1016/s0968-0896(02)00540-0. Bioorg Med Chem. 2003. PMID: 12537998
Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles.
Nishizawa R, Nishiyama T, Hisaichi K, Hirai K, Habashita H, Takaoka Y, Tada H, Sagawa K, Shibayama S, Maeda K, Mitsuya H, Nakai H, Fukushima D, Toda M. Nishizawa R, et al. Among authors: nishiyama t. Bioorg Med Chem Lett. 2010 Jan 15;20(2):763-6. doi: 10.1016/j.bmcl.2009.11.018. Epub 2009 Nov 12. Bioorg Med Chem Lett. 2010. PMID: 20005712 Free PMC article.
Spirodiketopiperazine-based CCR5 antagonist: discovery of an antiretroviral drug candidate.
Nishizawa R, Nishiyama T, Hisaichi K, Minamoto C, Matsunaga N, Takaoka Y, Nakai H, Jenkinson S, Kazmierski WM, Tada H, Sagawa K, Shibayama S, Fukushima D, Maeda K, Mitsuya H. Nishizawa R, et al. Among authors: nishiyama t. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1141-5. doi: 10.1016/j.bmcl.2010.12.109. Epub 2010 Dec 28. Bioorg Med Chem Lett. 2011. PMID: 21256008 Free PMC article.
Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.
Nishizawa R, Nishiyama T, Hisaichi K, Minamoto C, Murota M, Takaoka Y, Nakai H, Tada H, Sagawa K, Shibayama S, Fukushima D, Maeda K, Mitsuya H. Nishizawa R, et al. Among authors: nishiyama t. Bioorg Med Chem. 2011 Jul 1;19(13):4028-42. doi: 10.1016/j.bmc.2011.05.022. Epub 2011 May 20. Bioorg Med Chem. 2011. PMID: 21658961 Free PMC article.
Discovery of new orally active prostaglandin D2 receptor antagonists.
Iwahashi M, Naganawa A, Kinoshita A, Shimabukuro A, Nishiyama T, Ogawa S, Matsunaga Y, Tsukamoto K, Okada Y, Matsumoto R, Nambu F, Oumi R, Odagaki Y, Katagi J, Yano K, Tani K, Nakai H, Toda M. Iwahashi M, et al. Among authors: nishiyama t. Bioorg Med Chem. 2011 Nov 15;19(22):6935-48. doi: 10.1016/j.bmc.2011.08.065. Epub 2011 Sep 2. Bioorg Med Chem. 2011. PMID: 21982795
1,533 results