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1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. doi: 10.1124/jpet.107.129007. Epub 2007 Sep 25. J Pharmacol Exp Ther. 2007. PMID: 17895400
Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease.
Capurso C, Solfrizzi V, Colacicco AM, D'Introno A, Frisardi V, Imbimbo BP, Lorusso M, Vendemiale G, Denitto M, Santamato A, Seripa D, Pilotto A, Fiore P, Capurso A, Panza F. Capurso C, et al. Among authors: imbimbo bp. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):177-82. doi: 10.1016/j.pnpbp.2009.10.022. Epub 2009 Nov 6. Prog Neuropsychopharmacol Biol Psychiatry. 2010. PMID: 19897004
Late-life depression, mild cognitive impairment, and dementia: possible continuum?
Panza F, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Imbimbo BP, Santamato A, Vendemiale G, Seripa D, Pilotto A, Capurso A, Solfrizzi V. Panza F, et al. Among authors: imbimbo bp. Am J Geriatr Psychiatry. 2010 Feb;18(2):98-116. doi: 10.1097/JGP.0b013e3181b0fa13. Am J Geriatr Psychiatry. 2010. PMID: 20104067 Review.
243 results