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Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.
Yeung BK, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, Leong SY, Tan J, Wong J, Keller-Maerki S, Fischli C, Goh A, Schmitt EK, Krastel P, Francotte E, Kuhen K, Plouffe D, Henson K, Wagner T, Winzeler EA, Petersen F, Brun R, Dartois V, Diagana TT, Keller TH. Yeung BK, et al. Among authors: krastel p. J Med Chem. 2010 Jul 22;53(14):5155-64. doi: 10.1021/jm100410f. J Med Chem. 2010. PMID: 20568778 Free PMC article.
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis.
Kurabachew M, Lu SH, Krastel P, Schmitt EK, Suresh BL, Goh A, Knox JE, Ma NL, Jiricek J, Beer D, Cynamon M, Petersen F, Dartois V, Keller T, Dick T, Sambandamurthy VK. Kurabachew M, et al. Among authors: krastel p. J Antimicrob Chemother. 2008 Oct;62(4):713-9. doi: 10.1093/jac/dkn269. Epub 2008 Jun 27. J Antimicrob Chemother. 2008. PMID: 18587134
4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
LaMarche MJ, Leeds JA, Dzink-Fox J, Gunderson K, Krastel P, Memmert K, Patane MA, Rann EM, Schmitt E, Tiamfook S, Wang B. LaMarche MJ, et al. Among authors: krastel p. J Med Chem. 2011 Apr 14;54(7):2517-21. doi: 10.1021/jm101602q. Epub 2011 Mar 15. J Med Chem. 2011. PMID: 21405087
Natural products as probes in pharmaceutical research.
Schmitt EK, Hoepfner D, Krastel P. Schmitt EK, et al. Among authors: krastel p. J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):249-60. doi: 10.1007/s10295-015-1691-9. Epub 2015 Oct 5. J Ind Microbiol Biotechnol. 2016. PMID: 26438431 Review.
Antibacterial and Solubility Optimization of Thiomuracin A.
LaMarche MJ, Leeds JA, Brewer J, Dean K, Ding J, Dzink-Fox J, Gamber G, Jain A, Kerrigan R, Krastel P, Lee K, Lombardo F, McKenney D, Neckermann G, Osborne C, Palestrant D, Patane MA, Rann EM, Robinson Z, Schmitt E, Stams T, Tiamfook S, Yu D, Whitehead L. LaMarche MJ, et al. Among authors: krastel p. J Med Chem. 2016 Jul 28;59(14):6920-8. doi: 10.1021/acs.jmedchem.6b00726. Epub 2016 Jul 12. J Med Chem. 2016. PMID: 27355833
Antibiotic optimization and chemical structure stabilization of thiomuracin A.
LaMarche MJ, Leeds JA, Dzink-Fox J, Gangl E, Krastel P, Neckermann G, Palestrant D, Patane MA, Rann EM, Tiamfook S, Yu D. LaMarche MJ, et al. Among authors: krastel p. J Med Chem. 2012 Aug 9;55(15):6934-41. doi: 10.1021/jm300783c. Epub 2012 Jul 31. J Med Chem. 2012. PMID: 22812377
Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties.
Krastel P, Roggo S, Schirle M, Ross NT, Perruccio F, Aspesi P Jr, Aust T, Buntin K, Estoppey D, Liechty B, Mapa F, Memmert K, Miller H, Pan X, Riedl R, Thibaut C, Thomas J, Wagner T, Weber E, Xie X, Schmitt EK, Hoepfner D. Krastel P, et al. Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10149-54. doi: 10.1002/anie.201505069. Epub 2015 Jul 15. Angew Chem Int Ed Engl. 2015. PMID: 26179970
39 results