Adams DR - Search Results

1

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

Christian F, Anthony DF, Vadrevu S, Riddell T, Day JP, McLeod R, Adams DR, Baillie GS, Houslay MD. Christian F, et al. Among authors: adams dr. Cell Signal. 2010 Oct;22(10):1576-96. doi: 10.1016/j.cellsig.2010.06.003. Epub 2010 Jun 19. Cell Signal. 2010. PMID: 20600853

2

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.

Sin YY, Edwards HV, Li X, Day JP, Christian F, Dunlop AJ, Adams DR, Zaccolo M, Houslay MD, Baillie GS. Sin YY, et al. Among authors: adams dr. J Mol Cell Cardiol. 2011 May;50(5):872-83. doi: 10.1016/j.yjmcc.2011.02.006. Epub 2011 Feb 18. J Mol Cell Cardiol. 2011. PMID: 21334344

3

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).

Day JP, Lindsay B, Riddell T, Jiang Z, Allcock RW, Abraham A, Sookup S, Christian F, Bogum J, Martin EK, Rae RL, Anthony D, Rosair GM, Houslay DM, Huston E, Baillie GS, Klussmann E, Houslay MD, Adams DR. Day JP, et al. Among authors: adams dr. J Med Chem. 2011 May 12;54(9):3331-47. doi: 10.1021/jm200070e. Epub 2011 Apr 13. J Med Chem. 2011. PMID: 21456625

4

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains.

Bolger GB, Dunlop AJ, Meng D, Day JP, Klussmann E, Baillie GS, Adams DR, Houslay MD. Bolger GB, et al. Among authors: adams dr. Cell Signal. 2015 Apr;27(4):756-69. doi: 10.1016/j.cellsig.2014.12.009. Epub 2014 Dec 27. Cell Signal. 2015. PMID: 25546709 Free PMC article.

5

Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.

Terry R, Cheung YF, Praestegaard M, Baillie GS, Huston E, Gall I, Adams DR, Houslay MD. Terry R, et al. Among authors: adams dr. Cell Signal. 2003 Oct;15(10):955-71. doi: 10.1016/s0898-6568(03)00092-5. Cell Signal. 2003. PMID: 12873709

6

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).

Cameron RT, Coleman RG, Day JP, Yalla KC, Houslay MD, Adams DR, Shoichet BK, Baillie GS. Cameron RT, et al. Among authors: adams dr. Biochem Pharmacol. 2013 May 1;85(9):1297-305. doi: 10.1016/j.bcp.2013.02.026. Epub 2013 Mar 5. Biochem Pharmacol. 2013. PMID: 23473803 Free PMC article.

7

RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells.

Kiely M, Adams DR, Hayes SL, O'Connor R, Baillie GS, Kiely PA. Kiely M, et al. Among authors: adams dr. Cell Signal. 2017 Jul;35:290-300. doi: 10.1016/j.cellsig.2016.09.001. Epub 2016 Sep 4. Cell Signal. 2017. PMID: 27600565 Free article.

8

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.

Houslay KF, Christian F, MacLeod R, Adams DR, Houslay MD, Baillie GS. Houslay KF, et al. Among authors: adams dr. Biochem J. 2017 Feb 15;474(4):597-609. doi: 10.1042/BCJ20160849. Epub 2016 Dec 19. Biochem J. 2017. PMID: 27993970 Free PMC article.

9

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.

Omar F, Findlay JE, Carfray G, Allcock RW, Jiang Z, Moore C, Muir AL, Lannoy M, Fertig BA, Mai D, Day JP, Bolger G, Baillie GS, Schwiebert E, Klussmann E, Pyne NJ, Ong ACM, Bowers K, Adam JM, Adams DR, Houslay MD, Henderson DJP. Omar F, et al. Among authors: adams dr. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329. doi: 10.1073/pnas.1822113116. Epub 2019 Jun 17. Proc Natl Acad Sci U S A. 2019. PMID: 31209056 Free PMC article.

10

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.

Houslay MD, Adams DR. Houslay MD, et al. Among authors: adams dr. Biochem J. 2003 Feb 15;370(Pt 1):1-18. doi: 10.1042/BJ20021698. Biochem J. 2003. PMID: 12444918 Free PMC article. Review.

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