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Page 1
Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge.
Bommakanti G, Citron MP, Hepler RW, Callahan C, Heidecker GJ, Najar TA, Lu X, Joyce JG, Shiver JW, Casimiro DR, ter Meulen J, Liang X, Varadarajan R. Bommakanti G, et al. Among authors: hepler rw. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13701-6. doi: 10.1073/pnas.1007465107. Epub 2010 Jul 6. Proc Natl Acad Sci U S A. 2010. PMID: 20615991 Free PMC article.
Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons.
Shughrue PJ, Acton PJ, Breese RS, Zhao WQ, Chen-Dodson E, Hepler RW, Wolfe AL, Matthews M, Heidecker GJ, Joyce JG, Villarreal SA, Kinney GG. Shughrue PJ, et al. Among authors: hepler rw. Neurobiol Aging. 2010 Feb;31(2):189-202. doi: 10.1016/j.neurobiolaging.2008.04.003. Neurobiol Aging. 2010. PMID: 18486276
Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates.
Bianchi E, Joyce JG, Miller MD, Finnefrock AC, Liang X, Finotto M, Ingallinella P, McKenna P, Citron M, Ottinger E, Hepler RW, Hrin R, Nahas D, Wu C, Montefiori D, Shiver JW, Pessi A, Kim PS. Bianchi E, et al. Among authors: hepler rw. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10655-60. doi: 10.1073/pnas.1004261107. Epub 2010 May 18. Proc Natl Acad Sci U S A. 2010. PMID: 20483992 Free PMC article.
Small molecule mimetics of an HIV-1 gp41 fusion intermediate as vaccine leads.
Caulfield MJ, Dudkin VY, Ottinger EA, Getty KL, Zuck PD, Kaufhold RM, Hepler RW, McGaughey GB, Citron M, Hrin RC, Wang YJ, Miller MD, Joyce JG. Caulfield MJ, et al. Among authors: hepler rw. J Biol Chem. 2010 Dec 24;285(52):40604-11. doi: 10.1074/jbc.M110.172197. Epub 2010 Oct 13. J Biol Chem. 2010. PMID: 20943652 Free PMC article.
Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to meningococcal outer membrane protein complex.
Przysiecki C, Lucas B, Mitchell R, Carapau D, Wen Z, Xu H, Wang XM, Nahas D, Wu C, Hepler R, Ottinger E, Ter Meulen J, Kaslow D, Shiver J, Nardin E. Przysiecki C, et al. Front Cell Infect Microbiol. 2012 Nov 30;2:146. doi: 10.3389/fcimb.2012.00146. eCollection 2012. Front Cell Infect Microbiol. 2012. PMID: 23226683 Free PMC article.
Stabilized trimeric peptide immunogens of the complete HIV-1 gp41 N-heptad repeat and their use as HIV-1 vaccine candidates.
Wu C, Raheem IT, Nahas DD, Citron M, Kim PS, Montefiori DC, Ottinger EA, Hepler RW, Hrin R, Patel SB, Soisson SM, Joyce JG. Wu C, et al. Among authors: hepler rw. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2317230121. doi: 10.1073/pnas.2317230121. Epub 2024 May 20. Proc Natl Acad Sci U S A. 2024. PMID: 38768344 Free PMC article.
A recombinant 63-kDa form of Bacillus anthracis protective antigen produced in the yeast Saccharomyces cerevisiae provides protection in rabbit and primate inhalational challenge models of anthrax infection.
Hepler RW, Kelly R, McNeely TB, Fan H, Losada MC, George HA, Woods A, Cope LD, Bansal A, Cook JC, Zang G, Cohen SL, Wei X, Keller PM, Leffel E, Joyce JG, Pitt L, Schultz LD, Jansen KU, Kurtz M. Hepler RW, et al. Vaccine. 2006 Mar 6;24(10):1501-14. doi: 10.1016/j.vaccine.2005.10.018. Epub 2005 Oct 21. Vaccine. 2006. PMID: 16271808
Immunogenicity and protective efficacy of Bacillus anthracis poly-gamma-D-glutamic acid capsule covalently coupled to a protein carrier using a novel triazine-based conjugation strategy.
Joyce J, Cook J, Chabot D, Hepler R, Shoop W, Xu Q, Stambaugh T, Aste-Amezaga M, Wang S, Indrawati L, Bruner M, Friedlander A, Keller P, Caulfield M. Joyce J, et al. J Biol Chem. 2006 Feb 24;281(8):4831-43. doi: 10.1074/jbc.M509432200. Epub 2005 Nov 17. J Biol Chem. 2006. PMID: 16293624 Free article.
27 results