Nicklaus MC - Search Results

1

Exploring Potential Binding Modes of Small Drug-like Molecules to the Polo-Box Domain of Human Polo-like Kinase 1.

Liao C, Park JE, Bang JK, Nicklaus MC, Lee KS. Liao C, et al. Among authors: nicklaus mc. ACS Med Chem Lett. 2010;1(3):110-114. doi: 10.1021/ml100020e. ACS Med Chem Lett. 2010. PMID: 20625469 Free PMC article.

2

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Sigano DM, et al. Among authors: nicklaus mc. J Med Chem. 2003 Apr 24;46(9):1571-9. doi: 10.1021/jm020476o. J Med Chem. 2003. PMID: 12699375

3

Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).

Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE. Tamamura H, et al. Among authors: nicklaus mc. J Med Chem. 2004 Sep 23;47(20):4858-64. doi: 10.1021/jm049723+. J Med Chem. 2004. PMID: 15369389

4

Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.

Oishi S, Karki RG, Kang SU, Wang X, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR Jr. Oishi S, et al. Among authors: nicklaus mc. J Med Chem. 2005 Feb 10;48(3):764-72. doi: 10.1021/jm0492709. J Med Chem. 2005. PMID: 15689160

5

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.

Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: nicklaus mc. J Med Chem. 2005 Sep 8;48(18):5738-48. doi: 10.1021/jm050352m. J Med Chem. 2005. PMID: 16134942 Free PMC article.

6

Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands.

Zhao XZ, Semenova EA, Liao C, Nicklaus M, Pommier Y, Burke TR Jr. Zhao XZ, et al. Bioorg Med Chem. 2006 Dec 1;14(23):7816-25. doi: 10.1016/j.bmc.2006.07.064. Epub 2006 Sep 26. Bioorg Med Chem. 2006. PMID: 16908168

7

Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the phosphotyrosyl+1 position of Grb2 SH2 domain-binding tripeptides.

Kang SU, Choi WJ, Oishi S, Lee K, Karki RG, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR Jr. Kang SU, et al. Among authors: nicklaus mc. J Med Chem. 2007 Apr 19;50(8):1978-82. doi: 10.1021/jm0614073. Epub 2007 Mar 20. J Med Chem. 2007. PMID: 17371004

8

Sculpting the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve recognition by herpes thymidine kinase.

Comin MJ, Agbaria R, Ben-Kasus T, Huleihel M, Liao C, Sun G, Nicklaus MC, Deschamps JR, Parrish DA, Marquez VE. Comin MJ, et al. Among authors: nicklaus mc. J Am Chem Soc. 2007 May 16;129(19):6216-22. doi: 10.1021/ja0688732. Epub 2007 Apr 24. J Am Chem Soc. 2007. PMID: 17451242

9

Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA.

Liao C, Karki RG, Marchand C, Pommier Y, Nicklaus MC. Liao C, et al. Among authors: nicklaus mc. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5361-5. doi: 10.1016/j.bmcl.2007.08.011. Epub 2007 Aug 11. Bioorg Med Chem Lett. 2007. PMID: 17719223

10

Directed discovery of agents targeting the Met tyrosine kinase domain by virtual screening.

Peach ML, Tan N, Choyke SJ, Giubellino A, Athauda G, Burke TR Jr, Nicklaus MC, Bottaro DP. Peach ML, et al. Among authors: nicklaus mc. J Med Chem. 2009 Feb 26;52(4):943-51. doi: 10.1021/jm800791f. J Med Chem. 2009. PMID: 19199650 Free PMC article.

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