Hirai K - Search Results

1

[Preclinical pharmacological profiles and clinical outcome of the novel melatonin-receptor agonist ramelteon (Rozerem 8 mg).].

Hirai K, Kato K, Nishikawa H, Yukuhiro N, Nishiyama K, Miyamoto M. Hirai K, et al. Nihon Yakurigaku Zasshi. 2010 Jul;136(1):51-60. doi: 10.1254/fpj.136.51. Nihon Yakurigaku Zasshi. 2010. PMID: 20628215 Review. Japanese. No abstract available.

2

Pharmacological characterization of M-II, the major human metabolite of ramelteon.

Nishiyama K, Nishikawa H, Kato K, Miyamoto M, Tsukamoto T, Hirai K. Nishiyama K, et al. Among authors: hirai k. Pharmacology. 2014;93(3-4):197-201. doi: 10.1159/000362459. Epub 2014 Jun 6. Pharmacology. 2014. PMID: 24923230

3

The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells.

Nishiyama K, Hirai K. Nishiyama K, et al. Among authors: hirai k. PLoS One. 2014 Jul 11;9(7):e102073. doi: 10.1371/journal.pone.0102073. eCollection 2014. PLoS One. 2014. PMID: 25013953 Free PMC article.

4

In vitro comparison of duration of action of melatonin agonists on melatonin MT1 receptor: possible link between duration of action and dissociation rate from receptor.

Nishiyama K, Hirai K. Nishiyama K, et al. Among authors: hirai k. Eur J Pharmacol. 2015 Jun 15;757:42-52. doi: 10.1016/j.ejphar.2015.03.009. Epub 2015 Mar 20. Eur J Pharmacol. 2015. PMID: 25797281

5

Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists.

Uchikawa O, Fukatsu K, Tokunoh R, Kawada M, Matsumoto K, Imai Y, Hinuma S, Kato K, Nishikawa H, Hirai K, Miyamoto M, Ohkawa S. Uchikawa O, et al. Among authors: hirai k. J Med Chem. 2002 Sep 12;45(19):4222-39. doi: 10.1021/jm0201159. J Med Chem. 2002. PMID: 12213063

6

The sleep-promoting action of ramelteon (TAK-375) in freely moving cats.

Miyamoto M, Nishikawa H, Doken Y, Hirai K, Uchikawa O, Ohkawa S. Miyamoto M, et al. Among authors: hirai k. Sleep. 2004 Nov 1;27(7):1319-25. doi: 10.1093/sleep/27.7.1319. Sleep. 2004. PMID: 15586784

7

Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist.

Kato K, Hirai K, Nishiyama K, Uchikawa O, Fukatsu K, Ohkawa S, Kawamata Y, Hinuma S, Miyamoto M. Kato K, et al. Among authors: hirai k. Neuropharmacology. 2005 Feb;48(2):301-10. doi: 10.1016/j.neuropharm.2004.09.007. Neuropharmacology. 2005. PMID: 15695169

8

Molecular cloning and pharmacological characterization of monkey MT1 and MT2 melatonin receptors showing high affinity for the agonist ramelteon.

Nishiyama K, Shintani Y, Hirai K, Yoshikubo S. Nishiyama K, et al. Among authors: hirai k. J Pharmacol Exp Ther. 2009 Sep;330(3):855-63. doi: 10.1124/jpet.109.155283. Epub 2009 Jun 25. J Pharmacol Exp Ther. 2009. PMID: 19556449

9

Synthesis of a novel series of benzocycloalkene derivatives as melatonin receptor agonists.

Fukatsu K, Uchikawa O, Kawada M, Yamano T, Yamashita M, Kato K, Hirai K, Hinuma S, Miyamoto M, Ohkawa S. Fukatsu K, et al. Among authors: hirai k. J Med Chem. 2002 Sep 12;45(19):4212-21. doi: 10.1021/jm020114g. J Med Chem. 2002. PMID: 12213062

10

Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats.

Hirai K, Kita M, Ohta H, Nishikawa H, Fujiwara Y, Ohkawa S, Miyamoto M. Hirai K, et al. J Biol Rhythms. 2005 Feb;20(1):27-37. doi: 10.1177/0748730404269890. J Biol Rhythms. 2005. PMID: 15654068

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