Koch U - Search Results

1

Structural characterization of the Hepatitis C Virus NS3 protease from genotype 3a: the basis of the genotype 1b vs. 3a inhibitor potency shift.

Gallo M, Bottomley MJ, Pennestri M, Eliseo T, Paci M, Koch U, Bazzo R, Summa V, Carfì A, Cicero DO. Gallo M, et al. Among authors: koch u. Virology. 2010 Sep 30;405(2):424-38. doi: 10.1016/j.virol.2010.05.035. Epub 2010 Jul 13. Virology. 2010. PMID: 20630554 Free article.

2

Binding of a noncovalent inhibitor exploiting the S' region stabilizes the hepatitis C virus NS3 protease conformation in the absence of cofactor.

Gallo M, Pennestri M, Bottomley MJ, Barbato G, Eliseo T, Paci M, Narjes F, De Francesco R, Summa V, Koch U, Bazzo R, Cicero DO. Gallo M, et al. Among authors: koch u. J Mol Biol. 2009 Jan 30;385(4):1142-55. doi: 10.1016/j.jmb.2008.11.017. Epub 2008 Nov 24. J Mol Biol. 2009. PMID: 19061898

3

Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus.

Ingallinella P, Fattori D, Altamura S, Steinkühler C, Koch U, Cicero D, Bazzo R, Cortese R, Bianchi E, Pessi A. Ingallinella P, et al. Among authors: koch u. Biochemistry. 2002 Apr 30;41(17):5483-92. doi: 10.1021/bi025603x. Biochemistry. 2002. PMID: 11969409

4

Phosphorous acid analogs of novel P2-P4 macrocycles as inhibitors of HCV-NS3 protease.

Pompei M, Francesco ME, Koch U, Liverton NJ, Summa V. Pompei M, et al. Among authors: koch u. Bioorg Med Chem Lett. 2009 May 1;19(9):2574-8. doi: 10.1016/j.bmcl.2009.03.038. Epub 2009 Mar 17. Bioorg Med Chem Lett. 2009. PMID: 19328685

5

Novel macrocyclic inhibitors of hepatitis C NS3/4A protease featuring a 2-amino-1,3-thiazole as a P4 carbamate replacement.

Di Francesco ME, Dessole G, Nizi E, Pace P, Koch U, Fiore F, Pesci S, Di Muzio J, Monteagudo E, Rowley M, Summa V. Di Francesco ME, et al. Among authors: koch u. J Med Chem. 2009 Nov 26;52(22):7014-28. doi: 10.1021/jm900524b. J Med Chem. 2009. PMID: 19856919

6

Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies.

Cicero DO, Barbato G, Koch U, Ingallinella P, Bianchi E, Nardi MC, Steinkühler C, Cortese R, Matassa V, De Francesco R, Pessi A, Bazzo R. Cicero DO, et al. Among authors: koch u. J Mol Biol. 1999 Jun 4;289(2):385-96. doi: 10.1006/jmbi.1999.2746. J Mol Biol. 1999. PMID: 10366512

7

Measurement of homonuclear three-bond J(H(N)Halpha) coupling constants in unlabeled peptides complexed with labeled proteins: application to a decapeptide inhibitor bound to the proteinase domain of the NS3 protein of hepatitis C virus (HCV).

Cicero DO, Barbato G, Koch U, Ingallinella P, Bianchi E, Sambucini S, Neddermann P, De Francesco R, Pessi A, Bazzo R. Cicero DO, et al. Among authors: koch u. J Biomol NMR. 2001 May;20(1):23-9. doi: 10.1023/a:1011281527761. J Biomol NMR. 2001. PMID: 11430752

8

In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor.

Trozzi C, Bartholomew L, Ceccacci A, Biasiol G, Pacini L, Altamura S, Narjes F, Muraglia E, Paonessa G, Koch U, De Francesco R, Steinkuhler C, Migliaccio G. Trozzi C, et al. Among authors: koch u. J Virol. 2003 Mar;77(6):3669-79. doi: 10.1128/jvi.77.6.3669-3679.2003. J Virol. 2003. PMID: 12610142 Free PMC article.

9

Inhibitors of the hepatitis C virus NS3 protease with basic amine functionality at the P3-amino acid N-terminus: discovery and optimization of a new series of P2-P4 macrocycles.

Harper S, Ferrara M, Crescenzi B, Pompei M, Palumbi MC, DiMuzio JM, Donghi M, Fiore F, Koch U, Liverton NJ, Pesci S, Petrocchi A, Rowley M, Summa V, Gardelli C. Harper S, et al. Among authors: koch u. J Med Chem. 2009 Aug 13;52(15):4820-37. doi: 10.1021/jm900372w. J Med Chem. 2009. PMID: 19624135

10

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.

Ontoria JM, Rydberg EH, Di Marco S, Tomei L, Attenni B, Malancona S, Martin Hernando JI, Gennari N, Koch U, Narjes F, Rowley M, Summa V, Carroll SS, Olsen DB, De Francesco R, Altamura S, Migliaccio G, Carfì A. Ontoria JM, et al. Among authors: koch u. J Med Chem. 2009 Aug 27;52(16):5217-27. doi: 10.1021/jm900517t. J Med Chem. 2009. PMID: 19877603

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