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The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.
Kodach LL, Wiercinska E, de Miranda NF, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, van Noesel CJ, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJ, Hardwick JC. Kodach LL, et al. Among authors: hommes dw. Gastroenterology. 2008 May;134(5):1332-41. doi: 10.1053/j.gastro.2008.02.059. Epub 2008 Mar 4. Gastroenterology. 2008. PMID: 18471510
Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.
Kodach LL, Jacobs RJ, Voorneveld PW, Wildenberg ME, Verspaget HW, van Wezel T, Morreau H, Hommes DW, Peppelenbosch MP, van den Brink GR, Hardwick JC. Kodach LL, et al. Among authors: hommes dw. Gut. 2011 Nov;60(11):1544-53. doi: 10.1136/gut.2011.237495. Epub 2011 May 6. Gut. 2011. PMID: 21551187
Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.
Voorneveld PW, Kodach LL, Jacobs RJ, Liv N, Zonnevylle AC, Hoogenboom JP, Biemond I, Verspaget HW, Hommes DW, de Rooij K, van Noesel CJ, Morreau H, van Wezel T, Offerhaus GJ, van den Brink GR, Peppelenbosch MP, Ten Dijke P, Hardwick JC. Voorneveld PW, et al. Among authors: hommes dw. Gastroenterology. 2014 Jul;147(1):196-208.e13. doi: 10.1053/j.gastro.2014.03.052. Epub 2014 Apr 3. Gastroenterology. 2014. PMID: 24704720
Clinical significance of stromal apoptosis in colorectal cancer.
Koelink PJ, Sier CF, Hommes DW, Lamers CB, Verspaget HW. Koelink PJ, et al. Among authors: hommes dw. Br J Cancer. 2009 Sep 1;101(5):765-73. doi: 10.1038/sj.bjc.6605220. Epub 2009 Aug 4. Br J Cancer. 2009. PMID: 19654576 Free PMC article.
254 results