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93 results

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Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.
Park MA, Mitchell C, Zhang G, Yacoub A, Allegood J, Häussinger D, Reinehr R, Larner A, Spiegel S, Fisher PB, Voelkel-Johnson C, Ogretmen B, Grant S, Dent P. Park MA, et al. Among authors: allegood j. Cancer Res. 2010 Aug 1;70(15):6313-24. doi: 10.1158/0008-5472.CAN-10-0999. Epub 2010 Jul 14. Cancer Res. 2010. PMID: 20631069 Free PMC article.
MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.
Park MA, Walker T, Martin AP, Allegood J, Vozhilla N, Emdad L, Sarkar D, Rahmani M, Graf M, Yacoub A, Koumenis C, Spiegel S, Curiel DT, Voelkel-Johnson C, Grant S, Fisher PB, Dent P. Park MA, et al. Among authors: allegood j. Mol Cancer Ther. 2009 May;8(5):1280-91. doi: 10.1158/1535-7163.MCT-09-0073. Epub 2009 May 5. Mol Cancer Ther. 2009. PMID: 19417161 Free PMC article.
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Yacoub A, Hamed HA, Allegood J, Mitchell C, Spiegel S, Lesniak MS, Ogretmen B, Dash R, Sarkar D, Broaddus WC, Grant S, Curiel DT, Fisher PB, Dent P. Yacoub A, et al. Among authors: allegood j. Cancer Res. 2010 Feb 1;70(3):1120-9. doi: 10.1158/0008-5472.CAN-09-4043. Epub 2010 Jan 26. Cancer Res. 2010. PMID: 20103619 Free PMC article.
A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.
Park MA, Hamed HA, Mitchell C, Cruickshanks N, Dash R, Allegood J, Dmitriev IP, Tye G, Ogretmen B, Spiegel S, Yacoub A, Grant S, Curiel DT, Fisher PB, Dent P. Park MA, et al. Among authors: allegood j. Mol Pharmacol. 2011 Mar;79(3):368-80. doi: 10.1124/mol.110.069484. Epub 2010 Nov 30. Mol Pharmacol. 2011. PMID: 21119025 Free PMC article.
ORMDL proteins regulate ceramide levels during sterile inflammation.
Cai L, Oyeniran C, Biswas DD, Allegood J, Milstien S, Kordula T, Maceyka M, Spiegel S. Cai L, et al. Among authors: allegood j. J Lipid Res. 2016 Aug;57(8):1412-22. doi: 10.1194/jlr.M065920. Epub 2016 Jun 16. J Lipid Res. 2016. PMID: 27313060 Free PMC article.
Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.
Lépine S, Allegood JC, Edmonds Y, Milstien S, Spiegel S. Lépine S, et al. J Biol Chem. 2011 Dec 30;286(52):44380-90. doi: 10.1074/jbc.M111.257519. Epub 2011 Nov 3. J Biol Chem. 2011. PMID: 22052905 Free PMC article.
Depletion of S1P phosphohydrolase-1 (SPP1), which degrades intracellular S1P, induces the unfolded protein response and endoplasmic reticulum stress-induced autophagy (Lepine, S., Allegood, J. C., Park, M., Dent, P., Milstien, S., and Spiegel, S. (2011) Cell Death D …
Depletion of S1P phosphohydrolase-1 (SPP1), which degrades intracellular S1P, induces the unfolded protein response and endoplasmic reticulu …
93 results