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The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.
Sharmeen S, Skrtic M, Sukhai MA, Hurren R, Gronda M, Wang X, Fonseca SB, Sun H, Wood TE, Ward R, Minden MD, Batey RA, Datti A, Wrana J, Kelley SO, Schimmer AD. Sharmeen S, et al. Among authors: gronda m. Blood. 2010 Nov 4;116(18):3593-603. doi: 10.1182/blood-2010-01-262675. Epub 2010 Jul 19. Blood. 2010. PMID: 20644115 Free article.
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
Carter BZ, Gronda M, Wang Z, Welsh K, Pinilla C, Andreeff M, Schober WD, Nefzi A, Pond GR, Mawji IA, Houghten RA, Ostresh J, Brandwein J, Minden MD, Schuh AC, Wells RA, Messner H, Chun K, Reed JC, Schimmer AD. Carter BZ, et al. Among authors: gronda m. Blood. 2005 May 15;105(10):4043-50. doi: 10.1182/blood-2004-08-3168. Epub 2005 Feb 1. Blood. 2005. PMID: 15687241 Free PMC article.
Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation.
Mawji IA, Simpson CD, Hurren R, Gronda M, Williams MA, Filmus J, Jonkman J, Da Costa RS, Wilson BC, Thomas MP, Reed JC, Glinsky GV, Schimmer AD. Mawji IA, et al. Among authors: gronda m. J Natl Cancer Inst. 2007 May 16;99(10):811-22. doi: 10.1093/jnci/djk182. J Natl Cancer Inst. 2007. PMID: 17505076
Cyproheptadine displays preclinical activity in myeloma and leukemia.
Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, Wang X, Beheshti Zavareh R, Jamal N, Messner H, Hedley DW, Datti A, Wrana JL, Zhu Y, Shi CX, Lee K, Tiedemann R, Trudel S, Stewart AK, Schimmer AD. Mao X, et al. Among authors: gronda m. Blood. 2008 Aug 1;112(3):760-9. doi: 10.1182/blood-2008-02-142687. Epub 2008 May 23. Blood. 2008. PMID: 18502826 Free article.
Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function.
Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, Reinhold VN, Ezzat S, Wrana J, Rose DR, Schachter H, Dennis JW, Schimmer AD. Beheshti Zavareh R, et al. Among authors: gronda m. Cancer Res. 2008 Aug 15;68(16):6688-97. doi: 10.1158/0008-5472.CAN-07-6833. Cancer Res. 2008. PMID: 18701493
A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death.
Wood TE, Dalili S, Simpson CD, Hurren R, Mao X, Saiz FS, Gronda M, Eberhard Y, Minden MD, Bilan PJ, Klip A, Batey RA, Schimmer AD. Wood TE, et al. Among authors: gronda m. Mol Cancer Ther. 2008 Nov;7(11):3546-55. doi: 10.1158/1535-7163.MCT-08-0569. Mol Cancer Ther. 2008. PMID: 19001437
93 results