Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

33 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Publication Date timeline is not available.
Page 1
Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.
Anselm L, Banner DW, Benz J, Zbinden KG, Himber J, Hilpert H, Huber W, Kuhn B, Mary JL, Otteneder MB, Panday N, Ricklin F, Stahl M, Thomi S, Haap W. Anselm L, et al. Among authors: haap w. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5313-9. doi: 10.1016/j.bmcl.2010.06.126. Epub 2010 Jul 1. Bioorg Med Chem Lett. 2010. PMID: 20650636
Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.
Zbinden KG, Anselm L, Banner DW, Benz J, Blasco F, Décoret G, Himber J, Kuhn B, Panday N, Ricklin F, Risch P, Schlatter D, Stahl M, Thomi S, Unger R, Haap W. Zbinden KG, et al. Among authors: haap w. Eur J Med Chem. 2009 Jul;44(7):2787-95. doi: 10.1016/j.ejmech.2008.12.025. Epub 2009 Jan 3. Eur J Med Chem. 2009. PMID: 19200624
Systematic investigation of halogen bonding in protein-ligand interactions.
Hardegger LA, Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Banner DW, Haap W, Diederich F. Hardegger LA, et al. Among authors: haap w. Angew Chem Int Ed Engl. 2011 Jan 3;50(1):314-8. doi: 10.1002/anie.201006781. Angew Chem Int Ed Engl. 2011. PMID: 21184410 No abstract available.
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
Hebeisen P, Haap W, Kuhn B, Mohr P, Wessel HP, Zutter U, Kirchner S, Ruf A, Benz J, Joseph C, Alvarez-Sánchez R, Gubler M, Schott B, Benardeau A, Tozzo E, Kitas E. Hebeisen P, et al. Among authors: haap w. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3237-42. doi: 10.1016/j.bmcl.2011.04.044. Epub 2011 Apr 20. Bioorg Med Chem Lett. 2011. PMID: 21550236
Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments.
Hardegger LA, Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Isshiki Y, Morikami K, Shimma N, Haap W, Banner DW, Diederich F. Hardegger LA, et al. Among authors: haap w. ChemMedChem. 2011 Nov 4;6(11):2048-54. doi: 10.1002/cmdc.201100353. Epub 2011 Sep 6. ChemMedChem. 2011. PMID: 21898833
Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L.
Ehmke V, Winkler E, Banner DW, Haap W, Schweizer WB, Rottmann M, Kaiser M, Freymond C, Schirmeister T, Diederich F. Ehmke V, et al. Among authors: haap w. ChemMedChem. 2013 Jun;8(6):967-75. doi: 10.1002/cmdc.201300112. Epub 2013 May 9. ChemMedChem. 2013. PMID: 23658062
33 results