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Page 1
Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.
Anselm L, Banner DW, Benz J, Zbinden KG, Himber J, Hilpert H, Huber W, Kuhn B, Mary JL, Otteneder MB, Panday N, Ricklin F, Stahl M, Thomi S, Haap W. Anselm L, et al. Among authors: stahl m. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5313-9. doi: 10.1016/j.bmcl.2010.06.126. Epub 2010 Jul 1. Bioorg Med Chem Lett. 2010. PMID: 20650636
Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.
Zbinden KG, Anselm L, Banner DW, Benz J, Blasco F, Décoret G, Himber J, Kuhn B, Panday N, Ricklin F, Risch P, Schlatter D, Stahl M, Thomi S, Unger R, Haap W. Zbinden KG, et al. Among authors: stahl m. Eur J Med Chem. 2009 Jul;44(7):2787-95. doi: 10.1016/j.ejmech.2008.12.025. Epub 2009 Jan 3. Eur J Med Chem. 2009. PMID: 19200624
Tyramine fragment binding to BACE-1.
Kuglstatter A, Stahl M, Peters JU, Huber W, Stihle M, Schlatter D, Benz J, Ruf A, Roth D, Enderle T, Hennig M. Kuglstatter A, et al. Among authors: stahl m. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1304-7. doi: 10.1016/j.bmcl.2008.01.032. Epub 2008 Jan 11. Bioorg Med Chem Lett. 2008. PMID: 18226904
A medicinal chemist's guide to molecular interactions.
Bissantz C, Kuhn B, Stahl M. Bissantz C, et al. Among authors: stahl m. J Med Chem. 2010 Jul 22;53(14):5061-84. doi: 10.1021/jm100112j. J Med Chem. 2010. PMID: 20345171 Free PMC article. Review. No abstract available.
A Real-World Perspective on Molecular Design.
Kuhn B, Guba W, Hert J, Banner D, Bissantz C, Ceccarelli S, Haap W, Körner M, Kuglstatter A, Lerner C, Mattei P, Neidhart W, Pinard E, Rudolph MG, Schulz-Gasch T, Woltering T, Stahl M. Kuhn B, et al. Among authors: stahl m. J Med Chem. 2016 May 12;59(9):4087-102. doi: 10.1021/acs.jmedchem.5b01875. Epub 2016 Feb 24. J Med Chem. 2016. PMID: 26878596
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.
Zbinden KG, Obst-Sander U, Hilpert K, Kühne H, Banner DW, Böhm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lavé T. Zbinden KG, et al. Among authors: stahl m. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. doi: 10.1016/j.bmcl.2005.04.079. Epub 2005 Oct 4. Bioorg Med Chem Lett. 2005. PMID: 16213138
Interactive and Versatile Navigation of Structural Databases.
Korb O, Kuhn B, Hert J, Taylor N, Cole J, Groom C, Stahl M. Korb O, et al. Among authors: stahl m. J Med Chem. 2016 May 12;59(9):4257-66. doi: 10.1021/acs.jmedchem.5b01756. Epub 2016 Jan 8. J Med Chem. 2016. PMID: 26745458
1,172 results