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Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma.
Penas-Prado M, Hess KR, Fisch MJ, Lagrone LW, Groves MD, Levin VA, De Groot JF, Puduvalli VK, Colman H, Volas-Redd G, Giglio P, Conrad CA, Salacz ME, Floyd JD, Loghin ME, Hsu SH, Gonzalez J, Chang EL, Woo SY, Mahajan A, Aldape KD, Yung WK, Gilbert MR; MD Anderson Community Clinical Oncology Program; Brain Tumor Trials Collaborative. Penas-Prado M, et al. Neuro Oncol. 2015 Feb;17(2):266-73. doi: 10.1093/neuonc/nou155. Epub 2014 Sep 19. Neuro Oncol. 2015. PMID: 25239666 Free PMC article. Clinical Trial.
MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy.
Bobustuc GC, Smith JS, Maddipatla S, Jeudy S, Limaye A, Isley B, Caparas ML, Constantino SM, Shah N, Baker CH, Srivenugopal KS, Baidas S, Konduri SD. Bobustuc GC, et al. Mol Med. 2012 Sep 7;18(1):913-29. doi: 10.2119/molmed.2012.00010. Mol Med. 2012. PMID: 22549111 Free PMC article.
MGMT inhibition in ER positive breast cancer leads to CDC2, TOP2A, AURKB, CDC20, KIF20A, Cyclin A2, Cyclin B2, Cyclin D1, ERα and Survivin inhibition and enhances response to temozolomide.
Bobustuc GC, Kassam AB, Rovin RA, Jeudy S, Smith JS, Isley B, Singh M, Paranjpe A, Srivenugopal KS, Konduri SD. Bobustuc GC, et al. Oncotarget. 2018 Jul 3;9(51):29727-29742. doi: 10.18632/oncotarget.25696. eCollection 2018 Jul 3. Oncotarget. 2018. PMID: 30038716 Free PMC article.
New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy.
Paranjpe A, Bailey NI, Konduri S, Bobustuc GC, Ali-Osman F, Yusuf MA, Punganuru SR, Madala HR, Basak D, Mostofa A, Srivenugopal KS. Paranjpe A, et al. Among authors: bobustuc gc. J Biomed Res. 2016 Sep;30(5):393-410. doi: 10.7555/JBR.30.20160040. Epub 2016 Jun 10. J Biomed Res. 2016. PMID: 27845303 Free PMC article.
Epidemiology of male breast cancer.
Konduri S, Singh M, Bobustuc G, Rovin R, Kassam A. Konduri S, et al. Breast. 2020 Dec;54:8-14. doi: 10.1016/j.breast.2020.08.010. Epub 2020 Aug 22. Breast. 2020. PMID: 32866903 Free PMC article.
16 results