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Page 1
Biaryl substituted hydantoin compounds as TACE inhibitors.
Yu W, Tong L, Kim SH, Wong MK, Chen L, Yang DY, Shankar BB, Lavey BJ, Zhou G, Kosinski A, Rizvi R, Li D, Feltz RJ, Piwinski JJ, Rosner KE, Shih NY, Siddiqui MA, Guo Z, Orth P, Shah H, Sun J, Umland S, Lundell DJ, Niu X, Kozlowski JA. Yu W, et al. Among authors: kozlowski ja. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5286-9. doi: 10.1016/j.bmcl.2010.06.134. Epub 2010 Jul 1. Bioorg Med Chem Lett. 2010. PMID: 20663669
Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor.
Kozlowski JA, Lowe DB, Guzik HS, Zhou G, Ruperto VB, Duffy RA, McQuade R, Crosby G, Taylor LA, Billard W, Binch H, Lachowicz JE. Kozlowski JA, et al. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2255-7. doi: 10.1016/s0960-894x(00)00438-8. Bioorg Med Chem Lett. 2000. PMID: 11055332
Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.
Boyle CD, Chackalamannil S, Clader JW, Greenlee WJ, Josien HB, Kaminski JJ, Kozlowski JA, McCombie SW, Nazareno DV, Tagat JR, Wang Y, Zhou G, Billard W, Binch H, Crosby G, Cohen-Williams M, Coffin VL, Cox KA, Grotz DE, Duffy RA, Ruperto V, Lachowicz JE. Boyle CD, et al. Among authors: kozlowski ja. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2311-4. doi: 10.1016/s0960-894x(01)00435-8. Bioorg Med Chem Lett. 2001. PMID: 11527721
Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands.
Kozlowski JA, Zhou G, Tagat JR, Lin SI, McCombie SW, Ruperto VB, Duffy RA, McQuade RA, Crosby G, Taylor LA, Billard W, Binch H, Lachowicz JE. Kozlowski JA, et al. Bioorg Med Chem Lett. 2002 Mar 11;12(5):791-4. doi: 10.1016/s0960-894x(02)00023-9. Bioorg Med Chem Lett. 2002. PMID: 11859004
Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family.
McCombie SW, Lin SI, Tagat JR, Nazareno D, Vice S, Ford J, Asberom T, Leone D, Kozlowski JA, Zhou G, Ruperto VB, Duffy RA, Lachowicz JE. McCombie SW, et al. Among authors: kozlowski ja. Bioorg Med Chem Lett. 2002 Mar 11;12(5):795-8. doi: 10.1016/s0960-894x(02)00024-0. Bioorg Med Chem Lett. 2002. PMID: 11859005
Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies.
Shankar BB, Lavey BJ, Zhou G, Spitler JA, Tong L, Rizvi R, Yang DY, Wolin R, Kozlowski JA, Shih NY, Wu J, Hipkin RW, Gonsiorek W, Lunn CA. Shankar BB, et al. Among authors: kozlowski ja. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4417-20. doi: 10.1016/j.bmcl.2005.07.023. Bioorg Med Chem Lett. 2005. PMID: 16115769
Characterization of peripheral human cannabinoid receptor (hCB2) expression and pharmacology using a novel radioligand, [35S]Sch225336.
Gonsiorek W, Hesk D, Chen SC, Kinsley D, Fine JS, Jackson JV, Bober LA, Deno G, Bian H, Fossetta J, Lunn CA, Kozlowski JA, Lavey B, Piwinski J, Narula SK, Lundell DJ, Hipkin RW. Gonsiorek W, et al. Among authors: kozlowski ja. J Biol Chem. 2006 Sep 22;281(38):28143-51. doi: 10.1074/jbc.M602364200. Epub 2006 Jun 5. J Biol Chem. 2006. PMID: 16754676 Free article.
97 results