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Assessment of the short-term safety and tolerability of a quantified 80 % ethanol extract from the stem bark of Nauclea pobeguinii (PR 259 CT1) in healthy volunteers: a clinical phase I study.
Mesia K, Cimanga K, Tona L, Mampunza MM, Ntamabyaliro N, Muanda T, Muyembe T, Totté J, Mets T, Pieters L, Vlietinck A. Mesia K, et al. Among authors: mets t. Planta Med. 2011 Jan;77(2):111-6. doi: 10.1055/s-0030-1250134. Epub 2010 Jul 21. Planta Med. 2011. PMID: 20665369 Clinical Trial.
Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 1: a clinical phase IIA trial.
Mesia K, Tona L, Mampunza MM, Ntamabyaliro N, Muanda T, Muyembe T, Cimanga K, Totté J, Mets T, Pieters L, Vlietinck AJ. Mesia K, et al. Among authors: mets t. Planta Med. 2012 Feb;78(3):211-8. doi: 10.1055/s-0031-1280359. Epub 2011 Nov 17. Planta Med. 2012. PMID: 22095262 Clinical Trial.
Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 2: a clinical phase IIB trial.
Mesia K, Tona L, Mampunza MM, Ntamabyaliro N, Muanda T, Muyembe T, Musuamba T, Mets T, Cimanga K, Totté J, Pieters L, Vlietinck AJ. Mesia K, et al. Among authors: mets t. Planta Med. 2012 Jun;78(9):853-60. doi: 10.1055/s-0031-1298488. Epub 2012 Apr 26. Planta Med. 2012. PMID: 22538476 Clinical Trial.
Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems.
Mets T, Kurata T, Ernits K, Johansson MJO, Craig SZ, Evora GM, Buttress JA, Odai R, Wallant KC, Nakamoto JA, Shyrokova L, Egorov AA, Doering CR, Brodiazhenko T, Laub MT, Tenson T, Strahl H, Martens C, Harms A, Garcia-Pino A, Atkinson GC, Hauryliuk V. Mets T, et al. Cell Host Microbe. 2024 Jul 10;32(7):1059-1073.e8. doi: 10.1016/j.chom.2024.05.003. Epub 2024 May 30. Cell Host Microbe. 2024. PMID: 38821063 Free article.
Uncovering new families and folds in the natural protein universe.
Durairaj J, Waterhouse AM, Mets T, Brodiazhenko T, Abdullah M, Studer G, Tauriello G, Akdel M, Andreeva A, Bateman A, Tenson T, Hauryliuk V, Schwede T, Pereira J. Durairaj J, et al. Among authors: mets t. Nature. 2023 Oct;622(7983):646-653. doi: 10.1038/s41586-023-06622-3. Epub 2023 Sep 13. Nature. 2023. PMID: 37704037 Free PMC article.
The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems.
Ernits K, Saha CK, Brodiazhenko T, Chouhan B, Shenoy A, Buttress JA, Duque-Pedraza JJ, Bojar V, Nakamoto JA, Kurata T, Egorov AA, Shyrokova L, Johansson MJO, Mets T, Rustamova A, Džigurski J, Tenson T, Garcia-Pino A, Strahl H, Elofsson A, Hauryliuk V, Atkinson GC. Ernits K, et al. Among authors: mets t. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305393120. doi: 10.1073/pnas.2305393120. Epub 2023 Aug 9. Proc Natl Acad Sci U S A. 2023. PMID: 37556498 Free PMC article.
A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains.
Kurata T, Saha CK, Buttress JA, Mets T, Brodiazhenko T, Turnbull KJ, Awoyomi OF, Oliveira SRA, Jimmy S, Ernits K, Delannoy M, Persson K, Tenson T, Strahl H, Hauryliuk V, Atkinson GC. Kurata T, et al. Among authors: mets t. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2102212119. doi: 10.1073/pnas.2102212119. Proc Natl Acad Sci U S A. 2022. PMID: 35121656 Free PMC article.
156 results