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A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species.
Shanmugam R, Kusumanchi P, Appaiah H, Cheng L, Crooks P, Neelakantan S, Peat T, Klaunig J, Matthews W, Nakshatri H, Sweeney CJ. Shanmugam R, et al. Among authors: nakshatri h. Int J Cancer. 2011 May 15;128(10):2481-94. doi: 10.1002/ijc.25587. Int J Cancer. 2011. PMID: 20669221 Free PMC article.
NF-kappaB and breast cancer.
Nakshatri H, Goulet RJ Jr. Nakshatri H, et al. Curr Probl Cancer. 2002 Sep-Oct;26(5):282-309. doi: 10.1067/mcn.2002.129977. Curr Probl Cancer. 2002. PMID: 12429950 Review. No abstract available.
Nuclear factor-kappaB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate.
Sweeney C, Li L, Shanmugam R, Bhat-Nakshatri P, Jayaprakasan V, Baldridge LA, Gardner T, Smith M, Nakshatri H, Cheng L. Sweeney C, et al. Among authors: nakshatri h. Clin Cancer Res. 2004 Aug 15;10(16):5501-7. doi: 10.1158/1078-0432.CCR-0571-03. Clin Cancer Res. 2004. PMID: 15328189
Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model.
Shanmugam R, Jayaprakasan V, Gokmen-Polar Y, Kelich S, Miller KD, Yip-Schneider M, Cheng L, Bhat-Nakshatri P, Sledge GW Jr, Nakshatri H, Zheng QH, Miller MA, DeGrado T, Hutchins GD, Sweeney CJ. Shanmugam R, et al. Among authors: nakshatri h. Prostate. 2006 Oct 1;66(14):1498-511. doi: 10.1002/pros.20482. Prostate. 2006. PMID: 16921510
194 results