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Page 1
Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo.
Levonen AL, Inkala M, Heikura T, Jauhiainen S, Jyrkkänen HK, Kansanen E, Määttä K, Romppanen E, Turunen P, Rutanen J, Ylä-Herttuala S. Levonen AL, et al. Among authors: jyrkkanen hk. Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):741-7. doi: 10.1161/01.ATV.0000258868.80079.4d. Epub 2007 Jan 25. Arterioscler Thromb Vasc Biol. 2007. PMID: 17255530
Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo.
Jyrkkänen HK, Kansanen E, Inkala M, Kivelä AM, Hurttila H, Heinonen SE, Goldsteins G, Jauhiainen S, Tiainen S, Makkonen H, Oskolkova O, Afonyushkin T, Koistinaho J, Yamamoto M, Bochkov VN, Ylä-Herttuala S, Levonen AL. Jyrkkänen HK, et al. Circ Res. 2008 Jul 3;103(1):e1-9. doi: 10.1161/CIRCRESAHA.108.176883. Epub 2008 Jun 5. Circ Res. 2008. PMID: 18535259
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. Kanninen K, et al. Among authors: jyrkkanen hk. Mol Cell Neurosci. 2008 Nov;39(3):302-13. doi: 10.1016/j.mcn.2008.07.010. Epub 2008 Jul 29. Mol Cell Neurosci. 2008. PMID: 18706502
Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid.
Kansanen E, Jyrkkänen HK, Volger OL, Leinonen H, Kivelä AM, Häkkinen SK, Woodcock SR, Schopfer FJ, Horrevoets AJ, Ylä-Herttuala S, Freeman BA, Levonen AL. Kansanen E, et al. Among authors: jyrkkanen hk. J Biol Chem. 2009 Nov 27;284(48):33233-41. doi: 10.1074/jbc.M109.064873. Epub 2009 Oct 5. J Biol Chem. 2009. PMID: 19808663 Free PMC article.
Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects.
Jauhiainen S, Häkkinen SK, Toivanen PI, Heinonen SE, Jyrkkänen HK, Kansanen E, Leinonen H, Levonen AL, Ylä-Herttuala S. Jauhiainen S, et al. Among authors: jyrkkanen hk. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1617-24. doi: 10.1161/ATVBAHA.111.225961. Epub 2011 Apr 7. Arterioscler Thromb Vasc Biol. 2011. PMID: 21474827
NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation.
Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen HK, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokki H, Tavi P, Heikkinen S, Levonen AL. Kuosmanen SM, et al. Among authors: jyrkkanen hk. Nucleic Acids Res. 2018 Feb 16;46(3):1124-1138. doi: 10.1093/nar/gkx1155. Nucleic Acids Res. 2018. PMID: 29161413 Free PMC article.
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