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Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.
Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, Kashyap M, Hu P, Maiuri T, Narala SR, Stambolic V, Squire J, Penninger J, Sanchez O, Triche TJ, Wood GA, Kirschner LS, Khokha R. Molyneux SD, et al. Among authors: kirschner ls. J Clin Invest. 2010 Sep;120(9):3310-25. doi: 10.1172/JCI42391. Epub 2010 Aug 9. J Clin Invest. 2010. PMID: 20697156 Free PMC article.
PKA signaling drives mammary tumorigenesis through Src.
Beristain AG, Molyneux SD, Joshi PA, Pomroy NC, Di Grappa MA, Chang MC, Kirschner LS, Privé GG, Pujana MA, Khokha R. Beristain AG, et al. Among authors: kirschner ls. Oncogene. 2015 Feb 26;34(9):1160-73. doi: 10.1038/onc.2014.41. Epub 2014 Mar 24. Oncogene. 2015. PMID: 24662820
Mutations in regulatory subunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes.
Bertherat J, Horvath A, Groussin L, Grabar S, Boikos S, Cazabat L, Libe R, René-Corail F, Stergiopoulos S, Bourdeau I, Bei T, Clauser E, Calender A, Kirschner LS, Bertagna X, Carney JA, Stratakis CA. Bertherat J, et al. Among authors: kirschner ls. J Clin Endocrinol Metab. 2009 Jun;94(6):2085-91. doi: 10.1210/jc.2008-2333. Epub 2009 Mar 17. J Clin Endocrinol Metab. 2009. PMID: 19293268 Free PMC article.
PRKAR1A and the evolution of pituitary tumors.
Kirschner LS. Kirschner LS. Mol Cell Endocrinol. 2010 Sep 15;326(1-2):3-7. doi: 10.1016/j.mce.2010.04.027. Epub 2010 May 6. Mol Cell Endocrinol. 2010. PMID: 20451576 Free PMC article. Review.
PRKAR1A deficiency impedes hypertrophy and reduces heart size.
Liu Y, Xia P, Chen J, Bandettini WP, Kirschner LS, Stratakis CA, Cheng Z. Liu Y, et al. Among authors: kirschner ls. Physiol Rep. 2020 Mar;8(6):e14405. doi: 10.14814/phy2.14405. Physiol Rep. 2020. PMID: 32212257 Free PMC article.
115 results