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Page 1
Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.
Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, Kashyap M, Hu P, Maiuri T, Narala SR, Stambolic V, Squire J, Penninger J, Sanchez O, Triche TJ, Wood GA, Kirschner LS, Khokha R. Molyneux SD, et al. J Clin Invest. 2010 Sep;120(9):3310-25. doi: 10.1172/JCI42391. Epub 2010 Aug 9. J Clin Invest. 2010. PMID: 20697156 Free PMC article.
PKA signaling drives mammary tumorigenesis through Src.
Beristain AG, Molyneux SD, Joshi PA, Pomroy NC, Di Grappa MA, Chang MC, Kirschner LS, Privé GG, Pujana MA, Khokha R. Beristain AG, et al. Among authors: molyneux sd. Oncogene. 2015 Feb 26;34(9):1160-73. doi: 10.1038/onc.2014.41. Epub 2014 Mar 24. Oncogene. 2015. PMID: 24662820
RANKL blockade prevents and treats aggressive osteosarcomas.
Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R. Chen Y, et al. Among authors: molyneux sd. Sci Transl Med. 2015 Dec 9;7(317):317ra197. doi: 10.1126/scitranslmed.aad0295. Sci Transl Med. 2015. PMID: 26659571
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.
Moriarity BS, Otto GM, Rahrmann EP, Rathe SK, Wolf NK, Weg MT, Manlove LA, LaRue RS, Temiz NA, Molyneux SD, Choi K, Holly KJ, Sarver AL, Scott MC, Forster CL, Modiano JF, Khanna C, Hewitt SM, Khokha R, Yang Y, Gorlick R, Dyer MA, Largaespada DA. Moriarity BS, et al. Among authors: molyneux sd. Nat Genet. 2015 Jun;47(6):615-24. doi: 10.1038/ng.3293. Epub 2015 May 11. Nat Genet. 2015. PMID: 25961939 Free PMC article.
Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.
Gorrini C, Gang BP, Bassi C, Wakeham A, Baniasadi SP, Hao Z, Li WY, Cescon DW, Li YT, Molyneux S, Penrod N, Lupien M, Schmidt EE, Stambolic V, Gauthier ML, Mak TW. Gorrini C, et al. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4472-7. doi: 10.1073/pnas.1324136111. Epub 2014 Feb 24. Proc Natl Acad Sci U S A. 2014. PMID: 24567396 Free PMC article.
Human somatic cell mutagenesis creates genetically tractable sarcomas.
Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvák Z, Lupien M, Mak TW, Khokha R. Molyneux SD, et al. Nat Genet. 2014 Sep;46(9):964-72. doi: 10.1038/ng.3065. Epub 2014 Aug 17. Nat Genet. 2014. PMID: 25129143
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.
Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML. Gorrini C, et al. Among authors: molyneux sd. J Exp Med. 2013 Jul 29;210(8):1529-44. doi: 10.1084/jem.20121337. Epub 2013 Jul 15. J Exp Med. 2013. PMID: 23857982 Free PMC article.
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.
Shimoda M, Principe S, Jackson HW, Luga V, Fang H, Molyneux SD, Shao YW, Aiken A, Waterhouse PD, Karamboulas C, Hess FM, Ohtsuka T, Okada Y, Ailles L, Ludwig A, Wrana JL, Kislinger T, Khokha R. Shimoda M, et al. Among authors: molyneux sd. Nat Cell Biol. 2014 Sep;16(9):889-901. doi: 10.1038/ncb3021. Epub 2014 Aug 24. Nat Cell Biol. 2014. PMID: 25150980
12 results