Sheth PR - Search Results

1

Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli.

Sheth PR, Ramanathan L, Ranchod A, Basso AD, Barrett D, Zhao J, Gray K, Liu YH, Zhang R, Le HV. Sheth PR, et al. Arch Biochem Biophys. 2010 Nov 15;503(2):191-201. doi: 10.1016/j.abb.2010.08.004. Epub 2010 Aug 10. Arch Biochem Biophys. 2010. PMID: 20699085

2

Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein.

Sheth PR, Basso A, Duca JS, Lesburg CA, Ogas P, Gray K, Nale L, Mannarino AF, Prongay AJ, Le HV. Sheth PR, et al. Biochemistry. 2009 Nov 24;48(46):11045-55. doi: 10.1021/bi900946r. Biochemistry. 2009. PMID: 19824700

3

Purification and characterization of truncated human AMPK alpha 2 beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells.

Ramanathan L, Sheth PR, Ogas P, Xiao L, Le HV. Ramanathan L, et al. Among authors: sheth pr. Protein Expr Purif. 2010 Mar;70(1):13-22. doi: 10.1016/j.pep.2009.10.007. Epub 2009 Oct 30. Protein Expr Purif. 2010. PMID: 19836452

4

Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain.

Sheth PR, Shipps GW Jr, Seghezzi W, Smith CK, Chuang CC, Sanden D, Basso AD, Vilenchik L, Gray K, Annis DA, Nickbarg E, Ma Y, Lahue B, Herbst R, Le HV. Sheth PR, et al. Biochemistry. 2010 Sep 28;49(38):8350-8. doi: 10.1021/bi1005283. Biochemistry. 2010. PMID: 20718440

5

SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics.

Basso AD, Liu M, Dai C, Gray K, Nale L, Tevar S, Lee S, Liang L, Ponery A, Yaremko B, Smith E, Tang H, Sheth PR, Siddiqui MA, Hicklin DJ, Kirschmeier P. Basso AD, et al. Among authors: sheth pr. Mol Cancer Ther. 2010 Nov;9(11):2993-3002. doi: 10.1158/1535-7163.MCT-10-0548. Epub 2010 Oct 26. Mol Cancer Ther. 2010. PMID: 20978164

6

Structural basis of CX-4945 binding to human protein kinase CK2.

Ferguson AD, Sheth PR, Basso AD, Paliwal S, Gray K, Fischmann TO, Le HV. Ferguson AD, et al. Among authors: sheth pr. FEBS Lett. 2011 Jan 3;585(1):104-10. doi: 10.1016/j.febslet.2010.11.019. Epub 2010 Nov 18. FEBS Lett. 2011. PMID: 21093442 Free article.

7

Affinity characterization-mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution.

Vilenchik LZ, Sheth PR, Chuang CC, Le HV. Vilenchik LZ, et al. Among authors: sheth pr. Anal Biochem. 2011 Nov 1;418(1):10-8. doi: 10.1016/j.ab.2011.06.007. Epub 2011 Jun 13. Anal Biochem. 2011. PMID: 21726521

8

Fully activated MEK1 exhibits compromised affinity for binding of allosteric inhibitors U0126 and PD0325901.

Sheth PR, Liu Y, Hesson T, Zhao J, Vilenchik L, Liu YH, Mayhood TW, Le HV. Sheth PR, et al. Biochemistry. 2011 Sep 20;50(37):7964-76. doi: 10.1021/bi200542r. Epub 2011 Aug 26. Biochemistry. 2011. PMID: 21793567

9

Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α.

Tawa P, Zhang L, Metwally E, Hou Y, McCoy MA, Seganish WM, Zhang R, Frank E, Sheth P, Hanisak J, Sondey C, Bauman D, Soriano A. Tawa P, et al. J Biol Chem. 2022 Sep;298(9):102284. doi: 10.1016/j.jbc.2022.102284. Epub 2022 Jul 19. J Biol Chem. 2022. PMID: 35868561 Free PMC article.

10

Selective small-molecule inhibition of an RNA structural element.

Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T. Howe JA, et al. Among authors: sheth pr. Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30. Nature. 2015. PMID: 26416753

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