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Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid.
Tsukahara T, Tsukahara R, Fujiwara Y, Yue J, Cheng Y, Guo H, Bolen A, Zhang C, Balazs L, Re F, Du G, Frohman MA, Baker DL, Parrill AL, Uchiyama A, Kobayashi T, Murakami-Murofushi K, Tigyi G. Tsukahara T, et al. Among authors: fujiwara y. Mol Cell. 2010 Aug 13;39(3):421-32. doi: 10.1016/j.molcel.2010.07.022. Mol Cell. 2010. PMID: 20705243 Free PMC article.
Biological functions of a novel lipid mediator, cyclic phosphatidic acid.
Murakami-Murofushi K, Uchiyama A, Fujiwara Y, Kobayashi T, Kobayashi S, Mukai M, Murofushi H, Tigyi G. Murakami-Murofushi K, et al. Among authors: fujiwara y. Biochim Biophys Acta. 2002 May 23;1582(1-3):1-7. doi: 10.1016/s1388-1981(02)00131-2. Biochim Biophys Acta. 2002. PMID: 12069804 Review.
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis.
Baker DL, Fujiwara Y, Pigg KR, Tsukahara R, Kobayashi S, Murofushi H, Uchiyama A, Murakami-Murofushi K, Koh E, Bandle RW, Byun HS, Bittman R, Fan D, Murph M, Mills GB, Tigyi G. Baker DL, et al. Among authors: fujiwara y. J Biol Chem. 2006 Aug 11;281(32):22786-93. doi: 10.1074/jbc.M512486200. Epub 2006 Jun 16. J Biol Chem. 2006. PMID: 16782709 Free PMC article.
Lysophospholipid signaling: beyond the EDGs.
Valentine WJ, Fujiwara Y, Tsukahara R, Tigyi G. Valentine WJ, et al. Among authors: fujiwara y. Biochim Biophys Acta. 2008 Mar;1780(3):597-605. doi: 10.1016/j.bbagen.2007.08.008. Epub 2007 Aug 25. Biochim Biophys Acta. 2008. PMID: 17931789 Free PMC article.
Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid.
Gupte R, Siddam A, Lu Y, Li W, Fujiwara Y, Panupinthu N, Pham TC, Baker DL, Parrill AL, Gotoh M, Murakami-Murofushi K, Kobayashi S, Mills GB, Tigyi G, Miller DD. Gupte R, et al. Among authors: fujiwara y. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7525-8. doi: 10.1016/j.bmcl.2010.09.115. Epub 2010 Oct 8. Bioorg Med Chem Lett. 2010. PMID: 21051230 Free PMC article.
Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.
Gotoh M, Fujiwara Y, Yue J, Liu J, Lee S, Fells J, Uchiyama A, Murakami-Murofushi K, Kennel S, Wall J, Patil R, Gupte R, Balazs L, Miller DD, Tigyi GJ. Gotoh M, et al. Among authors: fujiwara y. Biochem Soc Trans. 2012 Feb;40(1):31-6. doi: 10.1042/BST20110608. Biochem Soc Trans. 2012. PMID: 22260662 Free PMC article. Review.
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Fells JI, Lee SC, Fujiwara Y, Norman DD, Lim KG, Tsukahara R, Liu J, Patil R, Miller DD, Kirby RJ, Nelson S, Seibel W, Papoian R, Parrill AL, Baker DL, Bittman R, Tigyi G. Fells JI, et al. Among authors: fujiwara y. Mol Pharmacol. 2013 Sep;84(3):415-24. doi: 10.1124/mol.113.087080. Epub 2013 Jun 21. Mol Pharmacol. 2013. PMID: 23793291 Free PMC article.
4,261 results