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The classical complement cascade mediates CNS synapse elimination.
Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, Micheva KD, Mehalow AK, Huberman AD, Stafford B, Sher A, Litke AM, Lambris JD, Smith SJ, John SW, Barres BA. Stevens B, et al. Cell. 2007 Dec 14;131(6):1164-78. doi: 10.1016/j.cell.2007.10.036. Cell. 2007. PMID: 18083105 Free article.
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B. Hong S, et al. Among authors: stevens b. Science. 2016 May 6;352(6286):712-716. doi: 10.1126/science.aad8373. Epub 2016 Mar 31. Science. 2016. PMID: 27033548 Free PMC article.
A complement-microglial axis drives synapse loss during virus-induced memory impairment.
Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS. Vasek MJ, et al. Among authors: stevens b. Nature. 2016 Jun 23;534(7608):538-43. doi: 10.1038/nature18283. Nature. 2016. PMID: 27337340 Free PMC article.
1,217 results