Lavieri RR - Search Results

1

Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.

Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW. Lavieri RR, et al. J Med Chem. 2010 Sep 23;53(18):6706-19. doi: 10.1021/jm100814g. J Med Chem. 2010. PMID: 20735042 Free PMC article.

2

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.

Lewis JA, Scott SA, Lavieri R, Buck JR, Selvy PE, Stoops SL, Armstrong MD, Brown HA, Lindsley CW. Lewis JA, et al. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1916-20. doi: 10.1016/j.bmcl.2009.02.057. Epub 2009 Feb 20. Bioorg Med Chem Lett. 2009. PMID: 19268584 Free PMC article.

3

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.

Lavieri R, Scott SA, Lewis JA, Selvy PE, Armstrong MD, Alex Brown H, Lindsley CW. Lavieri R, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. doi: 10.1016/j.bmcl.2009.02.125. Epub 2009 Mar 6. Bioorg Med Chem Lett. 2009. PMID: 19299128 Free PMC article.

4

Phospholipase D: enzymology, functionality, and chemical modulation.

Selvy PE, Lavieri RR, Lindsley CW, Brown HA. Selvy PE, et al. Among authors: lavieri rr. Chem Rev. 2011 Oct 12;111(10):6064-119. doi: 10.1021/cr200296t. Epub 2011 Sep 22. Chem Rev. 2011. PMID: 21936578 Free PMC article. Review. No abstract available.

5

Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes.

Scott SA, Spencer CT, O'Reilly MC, Brown KA, Lavieri RR, Cho CH, Jung DI, Larock RC, Brown HA, Lindsley CW. Scott SA, et al. Among authors: lavieri rr. ACS Chem Biol. 2015 Feb 20;10(2):421-32. doi: 10.1021/cb500828m. Epub 2014 Nov 19. ACS Chem Biol. 2015. PMID: 25384256 Free PMC article.

6

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.

Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC. Pulley JM, et al. Among authors: lavieri rr. Assay Drug Dev Technol. 2017 Apr;15(3):113-119. doi: 10.1089/adt.2016.772. Epub 2017 Apr 5. Assay Drug Dev Technol. 2017. PMID: 28379727 Free PMC article.

7

Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study.

Werfel TA, Hicks DJ, Rahman B, Bendeman WE, Duvernay MT, Maeng JG, Hamm H, Lavieri RR, Joly MM, Pulley JM, Elion DL, Brantley-Sieders DM, Cook RS. Werfel TA, et al. Among authors: lavieri rr. Mol Cancer Ther. 2020 Dec;19(12):2454-2464. doi: 10.1158/1535-7163.MCT-19-1106. Epub 2020 Oct 8. Mol Cancer Ther. 2020. PMID: 33033174

8

Machine learning on drug-specific data to predict small molecule teratogenicity.

Challa AP, Beam AL, Shen M, Peryea T, Lavieri RR, Lippmann ES, Aronoff DM. Challa AP, et al. Among authors: lavieri rr. Reprod Toxicol. 2020 Aug;95:148-158. doi: 10.1016/j.reprotox.2020.05.004. Epub 2020 May 16. Reprod Toxicol. 2020. PMID: 32428651 Free PMC article.

9

When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data.

Pulley JM, Jerome RN, Zaleski NM, Shirey-Rice JK, Pruijssers AJ, Lavieri RR, Chettiar SN, Naylor HM, Aronoff DM, Edwards DA, Niswender CM, Dugan LL, Crofford LJ, Bernard GR, Holroyd KJ. Pulley JM, et al. Among authors: lavieri rr. Assay Drug Dev Technol. 2017 Dec;15(8):354-361. doi: 10.1089/adt.2017.821. Epub 2017 Dec 1. Assay Drug Dev Technol. 2017. PMID: 29193979 Free PMC article.

10

Motivation for Launching a Cancer Metastasis Inhibition (CMI) Program.

Pulley JM, Jerome RN, Ogletree ML, Bernard GR, Lavieri RR, Zaleski NM, Hong CC, Shirey-Rice JK, Arteaga CL, Mayer IA, Holroyd KJ, Cook RS. Pulley JM, et al. Among authors: lavieri rr. Target Oncol. 2018 Feb;13(1):61-68. doi: 10.1007/s11523-017-0542-1. Target Oncol. 2018. PMID: 29218624 Free PMC article. Review.

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