Coughlan L - Search Results

1

Gene delivery of a mutant TGFβ3 reduces markers of scar tissue formation after cutaneous wounding.

Waddington SN, Crossley R, Sheard V, Howe SJ, Buckley SM, Coughlan L, Gilham DE, Hawkins RE, McKay TR. Waddington SN, et al. Among authors: coughlan l. Mol Ther. 2010 Dec;18(12):2104-11. doi: 10.1038/mt.2010.174. Epub 2010 Aug 24. Mol Ther. 2010. PMID: 20736928 Free PMC article.

2

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors.

Alba R, Bradshaw AC, Coughlan L, Denby L, McDonald RA, Waddington SN, Buckley SM, Greig JA, Parker AL, Miller AM, Wang H, Lieber A, van Rooijen N, McVey JH, Nicklin SA, Baker AH. Alba R, et al. Among authors: coughlan l. Blood. 2010 Oct 14;116(15):2656-64. doi: 10.1182/blood-2009-12-260026. Epub 2010 Jul 7. Blood. 2010. PMID: 20610817 Free PMC article.

3

Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery.

Coughlan L, Bradshaw AC, Parker AL, Robinson H, White K, Custers J, Goudsmit J, Van Roijen N, Barouch DH, Nicklin SA, Baker AH. Coughlan L, et al. Mol Ther. 2012 Dec;20(12):2268-81. doi: 10.1038/mt.2012.162. Epub 2012 Aug 28. Mol Ther. 2012. PMID: 22929662 Free PMC article.

4

Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens.

Antrobus RD, Coughlan L, Berthoud TK, Dicks MD, Hill AV, Lambe T, Gilbert SC. Antrobus RD, et al. Among authors: coughlan l. Mol Ther. 2014 Mar;22(3):668-674. doi: 10.1038/mt.2013.284. Epub 2013 Dec 30. Mol Ther. 2014. PMID: 24374965 Free PMC article.

5

Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.

Coughlan L, Vallath S, Gros A, Giménez-Alejandre M, Van Rooijen N, Thomas GJ, Baker AH, Cascalló M, Alemany R, Hart IR. Coughlan L, et al. Hum Gene Ther. 2012 Sep;23(9):960-79. doi: 10.1089/hum.2011.218. Epub 2012 Aug 27. Hum Gene Ther. 2012. PMID: 22708837 Clinical Trial.

6

Coadministration of seasonal influenza vaccine and MVA-NP+M1 simultaneously achieves potent humoral and cell-mediated responses.

Antrobus RD, Berthoud TK, Mullarkey CE, Hoschler K, Coughlan L, Zambon M, Hill AV, Gilbert SC. Antrobus RD, et al. Among authors: coughlan l. Mol Ther. 2014 Jan;22(1):233-8. doi: 10.1038/mt.2013.162. Epub 2013 Jul 8. Mol Ther. 2014. PMID: 23831594 Free PMC article.

7

In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery.

Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, Marshall JF, Hart IR, Thomas GJ. Coughlan L, et al. J Virol. 2009 Jul;83(13):6416-28. doi: 10.1128/JVI.00445-09. Epub 2009 Apr 15. J Virol. 2009. PMID: 19369326 Free PMC article.

8

A single-shot adenoviral vaccine provides hemagglutinin stalk-mediated protection against heterosubtypic influenza challenge in mice.

Bliss CM, Freyn AW, Caniels TG, Leyva-Grado VH, Nachbagauer R, Sun W, Tan GS, Gillespie VL, McMahon M, Krammer F, Hill AVS, Palese P, Coughlan L. Bliss CM, et al. Among authors: coughlan l. Mol Ther. 2022 May 4;30(5):2024-2047. doi: 10.1016/j.ymthe.2022.01.011. Epub 2022 Jan 7. Mol Ther. 2022. PMID: 34999208 Free PMC article.

9

The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells.

Man YKS, Davies JA, Coughlan L, Pantelidou C, Blázquez-Moreno A, Marshall JF, Parker AL, Halldén G. Man YKS, et al. Among authors: coughlan l. Mol Cancer Ther. 2018 Feb;17(2):575-587. doi: 10.1158/1535-7163.MCT-17-0671. Mol Cancer Ther. 2018. PMID: 29367266

10

Tropism-modification strategies for targeted gene delivery using adenoviral vectors.

Coughlan L, Alba R, Parker AL, Bradshaw AC, McNeish IA, Nicklin SA, Baker AH. Coughlan L, et al. Viruses. 2010 Oct;2(10):2290-2355. doi: 10.3390/v2102290. Epub 2010 Oct 13. Viruses. 2010. PMID: 21994621 Free PMC article.

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