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Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated dephosphorylation of Bad and Foxo3A in CLL.
Pagano MA, Tibaldi E, Molino P, Frezzato F, Trimarco V, Facco M, Zagotto G, Ribaudo G, Leanza L, Peruzzo R, Szabò I, Visentin A, Frasson M, Semenzato G, Trentin L, Brunati AM. Pagano MA, et al. Among authors: frezzato f. Leukemia. 2019 May;33(5):1148-1160. doi: 10.1038/s41375-018-0288-5. Epub 2018 Oct 23. Leukemia. 2019. PMID: 30353029
Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia.
Trentin L, Frasson M, Donella-Deana A, Frezzato F, Pagano MA, Tibaldi E, Gattazzo C, Zambello R, Semenzato G, Brunati AM. Trentin L, et al. Among authors: frezzato f. Blood. 2008 Dec 1;112(12):4665-74. doi: 10.1182/blood-2008-02-139139. Epub 2008 Sep 2. Blood. 2008. PMID: 18768392 Free article.
Cortactin, another player in the Lyn signaling pathway, is over-expressed and alternatively spliced in leukemic cells from patients with B-cell chronic lymphocytic leukemia.
Gattazzo C, Martini V, Frezzato F, Trimarco V, Tibaldi E, Castelli M, Facco M, Zonta F, Brunati AM, Zambello R, Semenzato G, Trentin L. Gattazzo C, et al. Among authors: frezzato f. Haematologica. 2014 Jun;99(6):1069-77. doi: 10.3324/haematol.2013.090183. Epub 2014 Feb 14. Haematologica. 2014. PMID: 24532043 Free PMC article.
In Chronic Lymphocytic Leukemia the JAK2/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment.
Severin F, Frezzato F, Visentin A, Martini V, Trimarco V, Carraro S, Tibaldi E, Brunati AM, Piazza F, Semenzato G, Facco M, Trentin L. Severin F, et al. Among authors: frezzato f. Cancers (Basel). 2019 Dec 4;11(12):1939. doi: 10.3390/cancers11121939. Cancers (Basel). 2019. PMID: 31817171 Free PMC article.
60 results