Fynch S - Search Results

1

Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity.

Sachithanandan N, Fam BC, Fynch S, Dzamko N, Watt MJ, Wormald S, Honeyman J, Galic S, Proietto J, Andrikopoulos S, Hevener AL, Kay TW, Steinberg GR. Sachithanandan N, et al. Among authors: fynch s. Hepatology. 2010 Nov;52(5):1632-42. doi: 10.1002/hep.23861. Hepatology. 2010. PMID: 20799351

2

Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli.

Carrington EM, McKenzie MD, Jansen E, Myers M, Fynch S, Kos C, Strasser A, Kay TW, Scott CL, Allison J. Carrington EM, et al. Among authors: fynch s. Diabetes. 2009 Oct;58(10):2316-23. doi: 10.2337/db08-1602. Epub 2009 Jul 6. Diabetes. 2009. PMID: 19581414 Free PMC article.

3

Autoreactive cytotoxic T lymphocytes acquire higher expression of cytotoxic effector markers in the islets of NOD mice after priming in pancreatic lymph nodes.

Graham KL, Krishnamurthy B, Fynch S, Mollah ZU, Slattery R, Santamaria P, Kay TW, Thomas HE. Graham KL, et al. Among authors: fynch s. Am J Pathol. 2011 Jun;178(6):2716-25. doi: 10.1016/j.ajpath.2011.02.015. Am J Pathol. 2011. PMID: 21641394 Free PMC article.

4

The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse.

Mollah ZU, Wali J, McKenzie MD, Krishnamurthy B, Graham KL, Fynch S, Szanyi J, Santamaria P, Brodnicki T, Allison J, Strasser A, Kay TW, Thomas HE. Mollah ZU, et al. Among authors: fynch s. Apoptosis. 2011 Aug;16(8):822-30. doi: 10.1007/s10495-011-0615-z. Apoptosis. 2011. PMID: 21644000

5

Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance.

Sachithanandan N, Graham KL, Galic S, Honeyman JE, Fynch SL, Hewitt KA, Steinberg GR, Kay TW. Sachithanandan N, et al. Among authors: fynch sl. Diabetes. 2011 Aug;60(8):2023-31. doi: 10.2337/db11-0259. Epub 2011 Jun 6. Diabetes. 2011. PMID: 21646388 Free PMC article.

6

Complete diabetes protection despite delayed thymic tolerance in NOD8.3 TCR transgenic mice due to antigen-induced extrathymic deletion of T cells.

Krishnamurthy B, Chee J, Jhala G, Fynch S, Graham KL, Santamaria P, Morahan G, Allison J, Izon D, Thomas HE, Kay TW. Krishnamurthy B, et al. Among authors: fynch s. Diabetes. 2012 Feb;61(2):425-35. doi: 10.2337/db11-0948. Epub 2011 Dec 21. Diabetes. 2012. PMID: 22190647 Free PMC article.

7

Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression.

Graham KL, Krishnamurthy B, Fynch S, Ayala-Perez R, Slattery RM, Santamaria P, Thomas HE, Kay TW. Graham KL, et al. Among authors: fynch s. Eur J Immunol. 2012 Jul;42(7):1717-22. doi: 10.1002/eji.201242435. Epub 2012 Jun 12. Eur J Immunol. 2012. PMID: 22585671 Free article.

8

Deficiency in type I interferon signaling prevents the early interferon-induced gene signature in pancreatic islets but not type 1 diabetes in NOD mice.

Quah HS, Miranda-Hernandez S, Khoo A, Harding A, Fynch S, Elkerbout L, Brodnicki TC, Baxter AG, Kay TW, Thomas HE, Graham KL. Quah HS, et al. Among authors: fynch s. Diabetes. 2014 Mar;63(3):1032-40. doi: 10.2337/db13-1210. Epub 2013 Dec 18. Diabetes. 2014. PMID: 24353186

9

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity.

Wali JA, Rondas D, McKenzie MD, Zhao Y, Elkerbout L, Fynch S, Gurzov EN, Akira S, Mathieu C, Kay TW, Overbergh L, Strasser A, Thomas HE. Wali JA, et al. Among authors: fynch s. Cell Death Dis. 2014 Mar 13;5(3):e1124. doi: 10.1038/cddis.2014.88. Cell Death Dis. 2014. PMID: 24625983 Free PMC article.

10

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes.

Zhao Y, Scott NA, Fynch S, Elkerbout L, Wong WW, Mason KD, Strasser A, Huang DC, Kay TW, Thomas HE. Zhao Y, et al. Among authors: fynch s. Diabetologia. 2015 Jan;58(1):140-8. doi: 10.1007/s00125-014-3407-5. Epub 2014 Oct 10. Diabetologia. 2015. PMID: 25301392

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