Needs PW - Search Results

1

Deconjugation kinetics of glucuronidated phase II flavonoid metabolites by beta-glucuronidase from neutrophils.

Bartholomé R, Haenen G, Hollman CH, Bast A, Dagnelie PC, Roos D, Keijer J, Kroon PA, Needs PW, Arts IC. Bartholomé R, et al. Among authors: needs pw. Drug Metab Pharmacokinet. 2010;25(4):379-87. doi: 10.2133/dmpk.dmpk-10-rg-002. Drug Metab Pharmacokinet. 2010. PMID: 20814159 Free article.

2

Flavonoid glucuronides are substrates for human liver beta-glucuronidase.

O'Leary KA, Day AJ, Needs PW, Sly WS, O'Brien NM, Williamson G. O'Leary KA, et al. Among authors: needs pw. FEBS Lett. 2001 Aug 10;503(1):103-6. doi: 10.1016/s0014-5793(01)02684-9. FEBS Lett. 2001. PMID: 11513863 Free article.

3

Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides.

Berrin JG, McLauchlan WR, Needs P, Williamson G, Puigserver A, Kroon PA, Juge N. Berrin JG, et al. Eur J Biochem. 2002 Jan;269(1):249-58. doi: 10.1046/j.0014-2956.2001.02641.x. Eur J Biochem. 2002. PMID: 11784319 Free article.

4

Characterization of metabolites of hydroxycinnamates in the in vitro model of human small intestinal epithelium caco-2 cells.

Kern SM, Bennett RN, Needs PW, Mellon FA, Kroon PA, Garcia-Conesa MT. Kern SM, et al. Among authors: needs pw. J Agric Food Chem. 2003 Dec 31;51(27):7884-91. doi: 10.1021/jf030470n. J Agric Food Chem. 2003. PMID: 14690369

5

Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert).

Svehliková V, Bennett RN, Mellon FA, Needs PW, Piacente S, Kroon PA, Bao Y. Svehliková V, et al. Among authors: needs pw. Phytochemistry. 2004 Aug;65(16):2323-32. doi: 10.1016/j.phytochem.2004.07.011. Phytochemistry. 2004. PMID: 15381003

6

Identification of isomeric flavonoid glucuronides in urine and plasma by metal complexation and LC-ESI-MS/MS.

Davis BD, Needs PW, Kroon PA, Brodbelt JS. Davis BD, et al. Among authors: needs pw. J Mass Spectrom. 2006 Jul;41(7):911-20. doi: 10.1002/jms.1050. J Mass Spectrom. 2006. PMID: 16810646

7

Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2).

Williamson G, Aeberli I, Miguet L, Zhang Z, Sanchez MB, Crespy V, Barron D, Needs P, Kroon PA, Glavinas H, Krajcsi P, Grigorov M. Williamson G, et al. Drug Metab Dispos. 2007 Aug;35(8):1262-8. doi: 10.1124/dmd.106.014241. Epub 2007 May 3. Drug Metab Dispos. 2007. PMID: 17478601

8

Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.

Tribolo S, Lodi F, Connor C, Suri S, Wilson VG, Taylor MA, Needs PW, Kroon PA, Hughes DA. Tribolo S, et al. Among authors: needs pw. Atherosclerosis. 2008 Mar;197(1):50-6. doi: 10.1016/j.atherosclerosis.2007.07.040. Epub 2007 Sep 18. Atherosclerosis. 2008. PMID: 17880982

9

Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity.

Loke WM, Proudfoot JM, Stewart S, McKinley AJ, Needs PW, Kroon PA, Hodgson JM, Croft KD. Loke WM, et al. Among authors: needs pw. Biochem Pharmacol. 2008 Mar 1;75(5):1045-53. doi: 10.1016/j.bcp.2007.11.002. Epub 2007 Nov 12. Biochem Pharmacol. 2008. PMID: 18096136

10

Quercetin and its in vivo metabolites inhibit neutrophil-mediated low-density lipoprotein oxidation.

Loke WM, Proudfoot JM, McKinley AJ, Needs PW, Kroon PA, Hodgson JM, Croft KD. Loke WM, et al. Among authors: needs pw. J Agric Food Chem. 2008 May 28;56(10):3609-15. doi: 10.1021/jf8003042. Epub 2008 May 3. J Agric Food Chem. 2008. PMID: 18454540

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