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Multiple epithelial Na+ channel domains participate in subunit assembly.
Bruns JB, Hu B, Ahn YJ, Sheng S, Hughey RP, Kleyman TR. Bruns JB, et al. Among authors: hughey rp. Am J Physiol Renal Physiol. 2003 Oct;285(4):F600-9. doi: 10.1152/ajprenal.00095.2003. Epub 2003 May 27. Am J Physiol Renal Physiol. 2003. PMID: 12770839 Free article.
Epithelial sodium channels are activated by furin-dependent proteolysis.
Hughey RP, Bruns JB, Kinlough CL, Harkleroad KL, Tong Q, Carattino MD, Johnson JP, Stockand JD, Kleyman TR. Hughey RP, et al. J Biol Chem. 2004 Apr 30;279(18):18111-4. doi: 10.1074/jbc.C400080200. Epub 2004 Mar 7. J Biol Chem. 2004. PMID: 15007080 Free article.
MUC1 membrane trafficking is modulated by multiple interactions.
Kinlough CL, Poland PA, Bruns JB, Harkleroad KL, Hughey RP. Kinlough CL, et al. Among authors: hughey rp. J Biol Chem. 2004 Dec 17;279(51):53071-7. doi: 10.1074/jbc.M409360200. Epub 2004 Oct 7. J Biol Chem. 2004. PMID: 15471854 Free article.
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.
Sheng S, Carattino MD, Bruns JB, Hughey RP, Kleyman TR. Sheng S, et al. Among authors: hughey rp. Am J Physiol Renal Physiol. 2006 Jun;290(6):F1488-96. doi: 10.1152/ajprenal.00439.2005. Epub 2006 Jan 31. Am J Physiol Renal Physiol. 2006. PMID: 16449353 Free article.
We previously demonstrated that mutation of key residues within two furin cleavage consensus sites in alpha, or one site in gamma, blocked subunit proteolysis and inhibited channel activity when mutant channels were expressed in Xenopus laevis oocytes (Hughey RP, Br …
We previously demonstrated that mutation of key residues within two furin cleavage consensus sites in alpha, or one site in gamma, blocked s …
Recycling of MUC1 is dependent on its palmitoylation.
Kinlough CL, McMahan RJ, Poland PA, Bruns JB, Harkleroad KL, Stremple RJ, Kashlan OB, Weixel KM, Weisz OA, Hughey RP. Kinlough CL, et al. Among authors: hughey rp. J Biol Chem. 2006 Apr 28;281(17):12112-22. doi: 10.1074/jbc.M512996200. Epub 2006 Feb 28. J Biol Chem. 2006. PMID: 16507569 Free article.
98 results