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The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia.
Heni M, Ketterer C, Hart LM, Ranta F, van Haeften TW, Eekhoff EM, Dekker JM, Boomsma DI, Nijpels G, Kramer MH, Diamant M, Simonis-Bik AM, Heine RJ, de Geus EJ, Schäfer SA, Machicao F, Ullrich S, Thamer C, Stefan N, Staiger H, Häring HU, Fritsche A. Heni M, et al. Among authors: ranta f. J Clin Endocrinol Metab. 2010 Dec;95(12):E479-84. doi: 10.1210/jc.2010-0860. Epub 2010 Sep 8. J Clin Endocrinol Metab. 2010. PMID: 20826583
Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.
Weyrich P, Staiger H, Stancáková A, Schäfer SA, Kirchhoff K, Ullrich S, Ranta F, Gallwitz B, Stefan N, Machicao F, Kuusisto J, Laakso M, Fritsche A, Häring HU. Weyrich P, et al. Among authors: ranta f. BMC Med Genet. 2009 Aug 14;10:77. doi: 10.1186/1471-2350-10-77. BMC Med Genet. 2009. PMID: 19682370 Free PMC article.
Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction.
Hennige AM, Ranta F, Heinzelmann I, Düfer M, Michael D, Braumüller H, Lutz SZ, Lammers R, Drews G, Bosch F, Häring HU, Ullrich S. Hennige AM, et al. Among authors: ranta f. Diabetes. 2010 Jan;59(1):119-27. doi: 10.2337/db09-0512. Epub 2009 Oct 13. Diabetes. 2010. PMID: 19826167 Free PMC article.
Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.
Ranta F, Leveringhaus J, Theilig D, Schulz-Raffelt G, Hennige AM, Hildebrand DG, Handrick R, Jendrossek V, Bosch F, Schulze-Osthoff K, Häring HU, Ullrich S. Ranta F, et al. PLoS One. 2011;6(12):e28828. doi: 10.1371/journal.pone.0028828. Epub 2011 Dec 27. PLoS One. 2011. PMID: 22216119 Free PMC article.
15 results