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Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume.
Acton JJ 3rd, Akiyama TE, Chang CH, Colwell L, Debenham S, Doebber T, Einstein M, Liu K, McCann ME, Moller DE, Muise ES, Tan Y, Thompson JR, Wong KK, Wu M, Xu L, Meinke PT, Berger JP, Wood HB. Acton JJ 3rd, et al. Among authors: wong kk. J Med Chem. 2009 Jul 9;52(13):3846-54. doi: 10.1021/jm900097m. J Med Chem. 2009. PMID: 19507861
Novel transcriptome profiling analyses demonstrate that selective peroxisome proliferator-activated receptor γ (PPARγ) modulators display attenuated and selective gene regulatory activity in comparison with PPARγ full agonists.
Tan Y, Muise ES, Dai H, Raubertas R, Wong KK, Thompson GM, Wood HB, Meinke PT, Lum PY, Thompson JR, Berger JP. Tan Y, et al. Among authors: wong kk. Mol Pharmacol. 2012 Jul;82(1):68-79. doi: 10.1124/mol.111.076679. Epub 2012 Apr 10. Mol Pharmacol. 2012. PMID: 22496518
A rapid method for cross-species quantitation of apolipoproteins A1, B48 and B100 in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.
Lassman ME, McLaughlin TM, Somers EP, Stefanni AC, Chen Z, Murphy BA, Bierilo KK, Flattery AM, Wong KK, Castro-Perez JM, Hubbard BK, Roddy TP. Lassman ME, et al. Among authors: wong kk. Rapid Commun Mass Spectrom. 2012 Jan 30;26(2):101-8. doi: 10.1002/rcm.5296. Rapid Commun Mass Spectrom. 2012. PMID: 22173797
Validation of human ApoB and ApoAI immunoturbidity assays for non-human primate dyslipidemia and atherosclerosis research.
Chen Z, Strack AM, Stefanni AC, Chen Y, Wu W, Pan Y, Urosevic-Price O, Wang L, McLaughlin T, Geoghagen N, Lassman ME, Roddy TP, Wong KK, Hubbard BK, Flattery AM. Chen Z, et al. Among authors: wong kk. J Cardiovasc Transl Res. 2011 Jun;4(3):373-83. doi: 10.1007/s12265-011-9264-4. Epub 2011 Mar 11. J Cardiovasc Transl Res. 2011. PMID: 21394531
Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.
Castro-Perez JM, Roddy TP, Shah V, Wang SP, Ouyang X, Ogawa A, McLaren DG, Tadin-Strapps M, Robinson MJ, Bartz SR, Ason B, Chen Y, Previs SF, Wong KK, Vreeken RJ, Johns DG, Hubbard BK, Hankemeier T, Mitnaul L. Castro-Perez JM, et al. Among authors: wong kk. J Proteome Res. 2011 Oct 7;10(10):4683-91. doi: 10.1021/pr200475g. Epub 2011 Aug 26. J Proteome Res. 2011. PMID: 21819150
1,817 results